| Literature DB >> 11532569 |
E Peira1, P Scolari, M R Gasco.
Abstract
The in vitro transdermal absorption of apomorphine from microemulsions was studied using the skin of the hairless mouse as a membrane. Two microemulsions (no. 1 and 2) were prepared and thickened both containing 3.9% of apomorphine hydrochloride. The lipophilicity of the drug was increased by forming apomorphine-octanoic acid ion-pairs. The fluxes of the drug from the microemulsions through hairless mouse skin were 100 microg h(-1) cm(-2) from no. 1 and 88 microg h(-1) cm(-2) from no. 2. Apomorphine in microemulsions, protected from light with antioxidants, showed no degradation for up to 6 months.Entities:
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Year: 2001 PMID： 11532569 DOI： 10.1016/s0378-5173(01)00759-1
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875