| Literature DB >> 11532402 |
Abstract
States of developmental commitment are encoded as combinations of transcription factors and changes in their expression can bring about transdifferentiation or metaplasia. For example, ectopic expressions of Vestigial can convert Drosophila leg to wing; of C/EBPbeta can convert pancreatic exocrine cells to hepatocytes; and expression of C/EBPalpha and PPARgamma can convert myoblasts to adipocytes.Entities:
Mesh:
Year: 2001 PMID: 11532402 DOI: 10.1016/s0959-437x(00)00236-7
Source DB: PubMed Journal: Curr Opin Genet Dev ISSN: 0959-437X Impact factor: 5.578