Mast cells and multiple sclerosis: a quantitative analysis.

The average number of mast cells observed in multiple sclerosis (MS) plaques from four patients, was 0.35 mast cells per mm2. This number represents 1/100 of the amount found in normal human skin. Most mast cells were observed in the border zones of the MS plaques and were clustered in restricted areas along venules and capillaries, which represent the main area of oedema formation in the brain. This cell type may be considered as a contributor to the pathogenesis of oedema formation and subsequent myelin destruction in MS.