| Literature DB >> 11530939 |
K Kaufmann1, K Bach, G Thiel.
Abstract
The zinc finger protein early growth response 1 (Egr-1) is a transcriptional activator involved in the regulation of growth and differentiation. We show here that a constitutive active mutant of mitogen-activated kinase kinase-1 (MAPKK-1) strongly stimulates the activity of the Egr-1 promoter, thus explaining the effects of mitogens upon Egr-1 mRNA and protein levels. Moreover, we show that a constitutive active MAPKK-1 leads to an increase in the biological activity of Egr-1 to activate transcription. We conclude that the signaling pathway involving mitogen-activated protein kinase/extracellular signal-regulated protein kinase has a dual impact on the biology of Egr-1 by controlling the transcription of the Egr-1 gene and the transcriptional activity of the Egr-1 protein.Entities:
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Year: 2001 PMID： 11530939 DOI： 10.1515/BC.2001.135
Source DB: PubMed Journal: Biol Chem ISSN： 1431-6730 Impact factor: 3.915