UNLABELLED: This study was carried out to examine the effect of antenatal corticosteroid therapy on pregnancies complicated by premature rupture of membranes (PROMs). For this purpose, 139 patients with a singleton pregnancy (27-34 weeks of gestation) complicated by PROMs were evaluated prospectively during the period January 1997 to February 1999 at two Jordanian military hospitals (Prince Rhashed and Prince Zaid). Patients were allocated into two groups; Group 1 included 72 patients treated with dexamethsone (24 mg divided into 4 doses 12 hours apart), and Group 2 which included 67 patients whoreceived no treatment (control group). All women were examined clinically and the diagnosis of PROMs was demonstrated using vaginal speculum, nitrazine paper examination and ultrasonography. All neonates were evaluated clinically, radiologically, and by laboratory investigations. Pearson's Chi-square and Fisher's exact tests were used to assess the significance of differences between the two study groups. Respiratory distress syndrome (RDS), necrotizing enterocolitis (NEC), intraventricular haemorrhage (IVH), and days of hospital stay were significantly reduced in premature infants of the corticosteroid treated women compared with the controls (p<0.04, p<0.04, p<0.04, and p<0.05, respectively). The perinatal mortality was significantly decreased among the corticosteroid treated group in the gestational subgroups 31-32 and 33-34 weeks (p<0.04), and in all birth weight subgroups (p<0.03). RDS was statistically a significant factor which resulted in increased perinatal mortality in the control group (p=0.02). Regarding the occurrence of postpartum endometritis there was a statistically significant increase among the corticosteroid treated group compared with the controls (p<0.04). CONCLUSION:Antenatal corticosteroid therapy in pregnancies complicated by PROMs has a positive influencing effect on premature infants between 31 and 34 weeks of gestation, decreasing significantly the perinatal morbidity and mortality. It should be used with particular relevance to the developing world where surfactant is not available or where neonatal intensive care units are lacking.
RCT Entities:
UNLABELLED: This study was carried out to examine the effect of antenatal corticosteroid therapy on pregnancies complicated by premature rupture of membranes (PROMs). For this purpose, 139 patients with a singleton pregnancy (27-34 weeks of gestation) complicated by PROMs were evaluated prospectively during the period January 1997 to February 1999 at two Jordanian military hospitals (Prince Rhashed and Prince Zaid). Patients were allocated into two groups; Group 1 included 72 patients treated with dexamethsone (24 mg divided into 4 doses 12 hours apart), and Group 2 which included 67 patients whoreceived no treatment (control group). All women were examined clinically and the diagnosis of PROMs was demonstrated using vaginal speculum, nitrazine paper examination and ultrasonography. All neonates were evaluated clinically, radiologically, and by laboratory investigations. Pearson's Chi-square and Fisher's exact tests were used to assess the significance of differences between the two study groups. Respiratory distress syndrome (RDS), necrotizing enterocolitis (NEC), intraventricular haemorrhage (IVH), and days of hospital stay were significantly reduced in premature infants of the corticosteroid treated women compared with the controls (p<0.04, p<0.04, p<0.04, and p<0.05, respectively). The perinatal mortality was significantly decreased among the corticosteroid treated group in the gestational subgroups 31-32 and 33-34 weeks (p<0.04), and in all birth weight subgroups (p<0.03). RDS was statistically a significant factor which resulted in increased perinatal mortality in the control group (p=0.02). Regarding the occurrence of postpartum endometritis there was a statistically significant increase among the corticosteroid treated group compared with the controls (p<0.04). CONCLUSION: Antenatal corticosteroid therapy in pregnancies complicated by PROMs has a positive influencing effect on premature infants between 31 and 34 weeks of gestation, decreasing significantly the perinatal morbidity and mortality. It should be used with particular relevance to the developing world where surfactant is not available or where neonatal intensive care units are lacking.
Authors: Elizabeth M McClure; Joseph de Graft-Johnson; Alan H Jobe; Steve Wall; Marge Koblinsky; Allisyn Moran; Linda L Wright; Winifride Mwebesa; Marion Koso-Thomas; Robert L Goldenberg Journal: Int J Gynaecol Obstet Date: 2011-09-17 Impact factor: 3.561
Authors: Joshua P Vogel; Olufemi T Oladapo; Cynthia Pileggi-Castro; Ebunoluwa A Adejuyigbe; Fernando Althabe; Shabina Ariff; Adejumoke Idowu Ayede; Abdullah H Baqui; Anthony Costello; Davy M Chikamata; Caroline Crowther; Bukola Fawole; Luz Gibbons; Alan H Jobe; Monica Lulu Kapasa; John Kinuthia; Alka Kriplani; Oluwafemi Kuti; James Neilson; Janna Patterson; Gilda Piaggio; Rahat Qureshi; Zahida Qureshi; Mari Jeeva Sankar; Jeffrey S A Stringer; Marleen Temmerman; Khalid Yunis; Rajiv Bahl; A Metin Gülmezoglu Journal: BMJ Glob Health Date: 2017-08-30
Authors: Olufemi T Oladapo; Joshua P Vogel; Gilda Piaggio; My-Huong Nguyen; Fernando Althabe; A Metin Gülmezoglu; Rajiv Bahl; Suman P N Rao; Ayesha De Costa; Shuchita Gupta; Abdullah H Baqui; Rasheda Khanam; Mohammod Shahidullah; Saleha B Chowdhury; Salahuddin Ahmed; Nazma Begum; Arunangshu D Roy; M A Shahed; Iffat A Jaben; Farida Yasmin; M Mozibur Rahman; Anjuman Ara; Soofia Khatoon; Gulshan Ara; Shaheen Akter; Nasreen Akhter; Probhat R Dey; M Abdus Sabur; Mohammad T Azad; Shahana F Choudhury; M A Matin; Shivaprasad S Goudar; Sangappa M Dhaded; Mrityunjay C Metgud; Yeshita V Pujar; Manjunath S Somannavar; Sunil S Vernekar; Veena R Herekar; Shailaja R Bidri; Sangamesh S Mathapati; Preeti G Patil; Mallanagouda M Patil; Muttappa R Gudadinni; Hidaytullah R Bijapure; Ashalata A Mallapur; Geetanjali M Katageri; Sumangala B Chikkamath; Bhuvaneshwari C Yelamali; Ramesh R Pol; Sujata S Misra; Leena Das; Saumya Nanda; Rashmita B Nayak; Bipsa Singh; Zahida Qureshi; Fredrick Were; Alfred Osoti; George Gwako; Ahmed Laving; John Kinuthia; Hafsa Mohamed; Nawal Aliyan; Adelaide Barassa; Elizabeth Kibaru; Margaret Mbuga; Lydia Thuranira; Njoroge J Githua; Bernadine Lusweti; Adejumoke I Ayede; Adegoke G Falade; Olubukola A Adesina; Atinuke M Agunloye; Oluwatosin O Iyiola; Wilfred Sanni; Ifeyinwa K Ejinkeonye; Hadiza A Idris; Chinyere V Okoli; Theresa A Irinyenikan; Omolayo A Olubosede; Olaseinde Bello; Olufemi M Omololu; Olanike A Olutekunbi; Adesina L Akintan; Olorunfemi O Owa; Rosena O Oluwafemi; Ireti P Eniowo; Adetokunbo O Fabamwo; Elizabeth A Disu; Joy O Agbara; Ebunoluwa A Adejuyigbe; Oluwafemi Kuti; Henry C Anyabolu; Ibraheem O Awowole; Akintunde O Fehintola; Bankole P Kuti; Anthony D Isah; Eyinade K Olateju; Olusanya Abiodun; Olabisi F Dedeke; Francis B Akinkunmi; Lawal Oyeneyin; Omotayo Adesiyun; Hadijat O Raji; Adedapo B A Ande; Ikechukwu Okonkwo; Shabina Ariff; Sajid B Soofi; Lumaan Sheikh; Saima Zulfiqar; Sadia Omer; Raheel Sikandar; Salma Sheikh; Daniel Giordano; Hugo Gamerro; Guillermo Carroli; Jose Carvalho; James Neilson; Elizabeth Molyneux; Khalid Yunis; Kidza Mugerwa; Harish K Chellani Journal: N Engl J Med Date: 2020-10-23 Impact factor: 91.245