Literature DB >> 11530800

Transforming growth factor beta, pleiotropic regulator of hematopoietic stem cells: potential physiological and clinical relevance.

F W Ruscetti1, S H Bartelmez.   

Abstract

Transforming growth factor beta (TGF-beta) is a pleiotropic regulator of all stages of hematopoieis. Depending on the differentiation stage of the target cell, the local environment, and the concentration of TGF-beta, TGF-beta can be proproliferative or antiproliferative, proapoptotic or antiapoptotic, and/or prodifferentiative or antidifferentiative. TGF-beta is the major regulator of stem cell quiescence and can act directly or indirectly through effects on the marrow microenvironment. In addition, paracrine and autocrine actions of TGF-beta have overlapping but distinct regulatory effects on hematopoietic stem/progenitor cells. Neutralization of autocrine TGF-beta has therapeutic potential.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11530800     DOI： 10.1007/BF02982545

Source DB:  PubMed          Journal:  Int J Hematol        ISSN： 0925-5710            Impact factor:   2.490


  42 in total

Review 1.  Stem cell homing: rolling, crawling, and nesting.

Authors:  P J Quesenberry; P S Becker
Journal:  Proc Natl Acad Sci U S A       Date:  1998-12-22       Impact factor: 11.205

2.  A neutralizing anti-TGF-beta1 antibody promotes proliferation of CD34+Thy-1+ peripheral blood progenitors and increases the number of transduced progenitors.

Authors:  A M Imbert; C Bagnis; R Galindo; C Chabannon; P Mannoni
Journal:  Exp Hematol       Date:  1998-05       Impact factor: 3.084

Review 3.  How cells read TGF-beta signals.

Authors:  J Massagué
Journal:  Nat Rev Mol Cell Biol       Date:  2000-12       Impact factor: 94.444

4.  Mechanisms that regulate the cell cycle status of very primitive hematopoietic cells in long-term human marrow cultures. II. Analysis of positive and negative regulators produced by stromal cells within the adherent layer.

Authors:  C J Eaves; J D Cashman; R J Kay; G J Dougherty; T Otsuka; L A Gaboury; D E Hogge; P M Lansdorp; A C Eaves; R K Humphries
Journal:  Blood       Date:  1991-07-01       Impact factor: 22.113

5.  Comparative effects of suppressive cytokines on isolated single CD34(3+) stem/progenitor cells from human bone marrow and umbilical cord blood plated with and without serum.

Authors:  L Lu; M Xiao; S Grigsby; W X Wang; B Wu; R N Shen; H E Broxmeyer
Journal:  Exp Hematol       Date:  1993-10       Impact factor: 3.084

6.  Release from quiescence of CD34+ CD38- human umbilical cord blood cells reveals their potentiality to engraft adults.

Authors:  A A Cardoso; M L Li; P Batard; A Hatzfeld; E L Brown; J P Levesque; H Sookdeo; B Panterne; P Sansilvestri; S C Clark
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-15       Impact factor: 11.205

7.  Autocrine transforming growth factor beta 1 blocks colony formation and progenitor cell generation by hemopoietic stem cells stimulated with steel factor.

Authors:  R E Ploemacher; P L van Soest; A Boudewijn
Journal:  Stem Cells       Date:  1993-07       Impact factor: 6.277

8.  Reduction in levels of the cyclin-dependent kinase inhibitor p27(kip-1) coupled with transforming growth factor beta neutralization induces cell-cycle entry and increases retroviral transduction of primitive human hematopoietic cells.

Authors:  M A Dao; N Taylor; J A Nolta
Journal:  Proc Natl Acad Sci U S A       Date:  1998-10-27       Impact factor: 11.205

9.  Distinct and overlapping direct effects of macrophage inflammatory protein-1 alpha and transforming growth factor beta on hematopoietic progenitor/stem cell growth.

Authors:  J R Keller; S H Bartelmez; E Sitnicka; F W Ruscetti; M Ortiz; J M Gooya; S E Jacobsen
Journal:  Blood       Date:  1994-10-01       Impact factor: 22.113

10.  Transforming growth factor beta directly regulates primitive murine hematopoietic cell proliferation.

Authors:  J R Keller; I K Mcniece; K T Sill; L R Ellingsworth; P J Quesenberry; G K Sing; F W Ruscetti
Journal:  Blood       Date:  1990-02-01       Impact factor: 22.113
View more
  12 in total

1.  Cytokines and hematology.

Authors:  S Kasakura
Journal:  Int J Hematol       Date:  2001-07       Impact factor: 2.490

Review 2.  TGF-β signaling and its role in the regulation of hematopoietic stem cells.

Authors:  Anuradha Vaidya; Vaijayanti P Kale
Journal:  Syst Synth Biol       Date:  2015-01-29

3.  TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia.

Authors:  A Willer; J S Jakobsen; E Ohlsson; N Rapin; J Waage; M Billing; L Bullinger; S Karlsson; B T Porse
Journal:  Leukemia       Date:  2014-10-28       Impact factor: 11.528

4.  Transforming growth factor-{beta}1 modulates responses of CD34+ cord blood cells to stromal cell-derived factor-1/CXCL12.

Authors:  Sunanda Basu; Hal E Broxmeyer
Journal:  Blood       Date:  2005-03-29       Impact factor: 22.113

Review 5.  Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease.

Authors:  Joanne E Murphy-Ullrich; Mark J Suto
Journal:  Matrix Biol       Date:  2017-12-27       Impact factor: 11.583

6.  Transforming growth factor-β1/Thrombospondin-1/CD47 axis mediates dysfunction in CD34+ cells derived from diabetic older adults.

Authors:  Jesmin Jahan; Ildamaris Monte de Oca; Brian Meissner; Shrinidh Joshi; Ahmad Maghrabi; Julio Quiroz-Olvera; Chrisitne Lopez-Yang; Stephen H Bartelmez; Charles Garcia; Yagna P Jarajapu
Journal:  Eur J Pharmacol       Date:  2022-02-23       Impact factor: 4.432

7.  Transient inhibition of transforming growth factor-beta1 in human diabetic CD34+ cells enhances vascular reparative functions.

Authors:  Ashay D Bhatwadekar; E P Guerin; Yagna P R Jarajapu; Sergio Caballero; Carl Sheridan; David Kent; Laurence Kennedy; M Cecilia Lansang; Frank W Ruscetti; Carl J Pepine; Paul J Higgins; Stephen H Bartelmez; Maria B Grant
Journal:  Diabetes       Date:  2010-05-11       Impact factor: 9.461

8.  Identification and characterization of genes involved in embryonic crystal cell formation during Drosophila hematopoiesis.

Authors:  Allison B Milchanowski; Amy L Henkenius; Maya Narayanan; Volker Hartenstein; Utpal Banerjee
Journal:  Genetics       Date:  2004-09       Impact factor: 4.562

Review 9.  The role of novel and known extracellular matrix and adhesion molecules in the homeostatic and regenerative bone marrow microenvironment.

Authors:  Sofieke Klamer; Carlijn Voermans
Journal:  Cell Adh Migr       Date:  2014       Impact factor: 3.405

10.  Crosstalk between the Smad and the Mitogen-Activated Protein Kinase Pathways is Essential for Erythroid Differentiation of Erythroleukemia Cells Induced by TGF-β, Activin, Hydroxyurea and Butyrate.

Authors:  Salem Akel; Daniel Bertolette; Francis W Ruscetti
Journal:  J Leuk (Los Angel)       Date:  2013-04-22
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.