M Kaneko1, T Sugawara, Y Tazawa. 1. Department of Ophthalmology, Iwate Medical University School of Medicine, 19-1 Uchimaru, Morioka 020-8505, Japan.
Abstract
PURPOSE: To evaluate behavior of the scotopic threshold response (STR) and the oscillatory potential (OP) in the electroretinogram (ERG) in streptozotocin (STZ)-induced diabetic rats (DM rats). METHODS: The amplitude of the STR and the OP 3, the implicit time of the STR, and the peak latency of the OP 3 of the DM rats were measured. RESULTS: No significant differences were observed in the mean amplitude or the mean implicit time of the STR between the control and the DM rats. On the other hand, the mean peak latency of OP 3 of the DM rats was significantly prolonged up to 125% of the control rats (p < 0.01), although there were no significant differences between the two groups in the mean OP 3 amplitude. CONCLUSIONS: Although both STR and OP were of inner retinal origin, their behavior was different in DM rats. This result supported some reports describing how dopaminergic amacrine cells generate OP and glycinergic or GABAergic amacrine cells generate STR. In the early stage of diabetic retinopathy, there may be not only minor ischemia but also disorder of neurotransmission of the amacrine cells in the inner retinal layers.
PURPOSE: To evaluate behavior of the scotopic threshold response (STR) and the oscillatory potential (OP) in the electroretinogram (ERG) in streptozotocin (STZ)-induced diabeticrats (DMrats). METHODS: The amplitude of the STR and the OP 3, the implicit time of the STR, and the peak latency of the OP 3 of the DMrats were measured. RESULTS: No significant differences were observed in the mean amplitude or the mean implicit time of the STR between the control and the DMrats. On the other hand, the mean peak latency of OP 3 of the DMrats was significantly prolonged up to 125% of the control rats (p < 0.01), although there were no significant differences between the two groups in the mean OP 3 amplitude. CONCLUSIONS: Although both STR and OP were of inner retinal origin, their behavior was different in DMrats. This result supported some reports describing how dopaminergic amacrine cells generate OP and glycinergic or GABAergic amacrine cells generate STR. In the early stage of diabetic retinopathy, there may be not only minor ischemia but also disorder of neurotransmission of the amacrine cells in the inner retinal layers.
Authors: Moon K Kim; Moe H Aung; Lukas Mees; Darin E Olson; Nikita Pozdeyev; P Michael Iuvone; Peter M Thule; Machelle T Pardue Journal: Invest Ophthalmol Vis Sci Date: 2018-01-01 Impact factor: 4.799