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Literature DB >> 11530278

Reflections on sterol sidechain cleavage process catalyzed by cytochrome P450(scc).

Abstract

The essay examines the evidence upon which the presently accepted version of the mechanism of the cytochrome P450(scc)-catalyzed-cleavage of the sidechain of cholesterol is based. This analysis indicates that the generally held view of the process (two consecutive hydroxylations, followed by cleavage of the resulting glycol) most likely does not describe the true mechanism. The available evidence can not be used to support this traditional notion. Two alternative hypotheses are proposed.

Entities: Chemical Gene

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Year: 2001 PMID： 11530278 DOI： 10.1016/s0960-0760(01)00068-1

Source DB: PubMed Journal: J Steroid Biochem Mol Biol ISSN： 0960-0760 Impact factor: 4.292

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Cited

6 in total

1. Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system.

Authors: Natallia Strushkevich; Farrell MacKenzie; Tatyana Cherkesova; Irina Grabovec; Sergey Usanov; Hee-Won Park
Journal: Proc Natl Acad Sci U S A Date: 2011-06-02 Impact factor: 11.205

2. In memoriam: Seymour Lieberman, hormonologist, chemist and humanist (1916-2012) National Academy of Sciences of the United States of America, member, and endocrine society, president, 1974-1975.

Authors: Etienne-Emile Baulieu
Journal: Mol Endocrinol Date: 2013-09

3. Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies.

Authors: Roman Davydov; Natallia Strushkevich; David Smil; Aliaksei Yantsevich; Andrey Gilep; Sergey Usanov; Brian M Hoffman
Journal: Biochemistry Date: 2015-11-25 Impact factor: 3.162

Reflections on sterol sidechain cleavage process catalyzed by cytochrome P450(scc).

1. Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system.

2. In memoriam: Seymour Lieberman, hormonologist, chemist and humanist (1916-2012) National Academy of Sciences of the United States of America, member, and endocrine society, president, 1974-1975.

3. Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing Studies.

4. The brain of teleost fish, a source, and a target of sexual steroids.

5. An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis.

Review 6. Multiple roles of hypoxia in bovine corpus luteum.