| Literature DB >> 11529781 |
M A Heuft1, S K Collins, G P Yap, A G Fallis.
Abstract
[reaction: see text]. An efficient method for the in situ desilylation/oxidative dimerization of (trialkylsilyl)acetylenes is described. This protocol avoids the complications encountered with sensitive diynes by eliminating the deprotection and isolation steps. Various aromatic and alkyl diynes and tetraynes can be synthesized in a straightforward manner in good yields (82-99%) from TIPS-protected acetylenes. This method facilitates the efficient synthesis of novel tetrayne-bridged acetylenic cyclophanes 6 and 7 in a direct manner.Entities:
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Year: 2001 PMID： 11529781 DOI： 10.1021/ol016414u
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005