Literature DB >> 11529778

Copper-mediated cross-coupling of functionalized arylmagnesium reagents with functionalized alkyl and benzylic halides.

W Dohle1, D M Lindsay, P Knochel.   

Abstract

[reaction: see text]. Functionalized arylmagnesium halides, prepared via an iodine-magnesium exchange, undergo a smooth cross-coupling reaction with functionalized primary alkyl iodides and benzylic bromides in the presence of CuCN.2LiCl, either in stoichiometric (with trimethyl phosphite as an additive) or catalytic quantities.

Entities:  

Year:  2001        PMID： 11529778     DOI： 10.1021/ol0163272

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

1.  Discovery of novel triazole-based opioid receptor antagonists.

Authors:  Qiang Zhang; Susan M Keenan; Youyi Peng; Anil C Nair; Seong Jae Yu; Richard D Howells; William J Welsh
Journal:  J Med Chem       Date:  2006-07-13       Impact factor: 7.446

2.  An efficient and general approach to beta-functionalized ketones.

Authors:  Jingliang Jiao; Larry X Nguyen; Dennis R Patterson; Robert A Flowers
Journal:  Org Lett       Date:  2007-03-03       Impact factor: 6.005

3.  "On water" sp3-sp2 cross-couplings between benzylic and alkenyl halides.

Authors:  Valeria Krasovskaya; Arkady Krasovskiy; Anish Bhattacharjya; Bruce H Lipshutz
Journal:  Chem Commun (Camb)       Date:  2011-04-12       Impact factor: 6.222

4.  Highly potent triazole-based tubulin polymerization inhibitors.

Authors:  Qiang Zhang; Youyi Peng; Xin I Wang; Susan M Keenan; Sonia Arora; William J Welsh
Journal:  J Med Chem       Date:  2007-01-24       Impact factor: 7.446

5.  Suzuki-Miyaura cross-coupling reactions of benzyl halides with potassium aryltrifluoroborates.

Authors:  Gary A Molander; Maxwell D Elia
Journal:  J Org Chem       Date:  2006-11-24       Impact factor: 4.354

6.  Water-soluble phosphinothiols for traceless staudinger ligation and integration with expressed protein ligation.

Authors:  Annie Tam; Matthew B Soellner; Ronald T Raines
Journal:  J Am Chem Soc       Date:  2007-08-22       Impact factor: 15.419

7.  Cross-couplings between benzylic and aryl halides "on water": synthesis of diarylmethanes.

Authors:  Christophe Duplais; Arkady Krasovskiy; Alina Wattenberg; Bruce H Lipshutz
Journal:  Chem Commun (Camb)       Date:  2009-12-09       Impact factor: 6.222
  7 in total

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