| Literature DB >> 11529745 |
T C McMorris1, J Yu, R Lira, R Dawe, J R MacDonald, S J Waters, L A Estes, M J Kelner.
Abstract
Many analogues of the antitumor agent irofulven have been readily prepared by replacing the allylic hydroxyl with a variety of nucleophiles. Analogues of acylfulvene (the precursor to irofulven) were also prepared by Michael reaction with acrolein. The toxicity of the analogues was determined, as well as preclinical antitumor activity. Several analogues exhibited good activity in mouse xenografts. Structural requirements for activity are discussed.Entities:
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Year: 2001 PMID： 11529745 DOI： 10.1021/jo010458z
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354