UNLABELLED: The aim of this study was to measure brainstem size on magnetic resonance imaging (MRI) scans of high-risk. preterm infants, to assess brainstem function by brainstem auditory-evoked potentials (BAEP) and to determine the predictive value of these measures for the neurosensory outcome. A total of 51 preterm infants (gestational age <34 wk, birthweight <1,500 g) underwent examinations at term age; neuromotor outcome and hearing were followed up until a corrected age of 18 mo. Fourteen (27%) infants had neurosensory disability. Those with a later neurosensory disability had a significantly smaller brain stem than those with a normal outcome. The preterm infants had significantly longer peak latency (L) V and interpeak latency (IPL) III-V than the full-term control infants. Most of the preterm infants with severe cerebral palsy or hearing loss had abnormal BAEP. Sensitivity of morphometric dimensions for predicting neurosensory disability was only 20-31%, but specificity was 97-100%. Abnormal L I and IPL III-V in BAEP predicted disability with a sensitivity of 93% and a specificity of 57-59%. CONCLUSION: We conclude that adverse events during the perinatal period may lead to morphofunctional changes in the brain stem in high-risk, preterm infants, and it seems that functional changes are accurate in predicting neurosensory disability in such patients.
UNLABELLED: The aim of this study was to measure brainstem size on magnetic resonance imaging (MRI) scans of high-risk. preterm infants, to assess brainstem function by brainstem auditory-evoked potentials (BAEP) and to determine the predictive value of these measures for the neurosensory outcome. A total of 51 preterm infants (gestational age <34 wk, birthweight <1,500 g) underwent examinations at term age; neuromotor outcome and hearing were followed up until a corrected age of 18 mo. Fourteen (27%) infants had neurosensory disability. Those with a later neurosensory disability had a significantly smaller brain stem than those with a normal outcome. The preterm infants had significantly longer peak latency (L) V and interpeak latency (IPL) III-V than the full-term control infants. Most of the preterm infants with severe cerebral palsy or hearing loss had abnormal BAEP. Sensitivity of morphometric dimensions for predicting neurosensory disability was only 20-31%, but specificity was 97-100%. Abnormal L I and IPL III-V in BAEP predicted disability with a sensitivity of 93% and a specificity of 57-59%. CONCLUSION: We conclude that adverse events during the perinatal period may lead to morphofunctional changes in the brain stem in high-risk, preterm infants, and it seems that functional changes are accurate in predicting neurosensory disability in such patients.
Authors: L Borenstein-Levin; R Taha; A Riskin; H Hafner; A Cohen-Vaizer; A Gordin; Y Littner; G Dinur; O Hochwald; A Kugelman Journal: Pediatr Res Date: 2021-11-17 Impact factor: 3.953
Authors: Milla Reiman; Riitta Parkkola; Reijo Johansson; Satu K Jääskeläinen; Harry Kujari; Liisa Lehtonen; Leena Haataja; Helena Lapinleimu Journal: Pediatr Radiol Date: 2009-05-09
Authors: Gareth Ball; Paul Aljabar; Phumza Nongena; Nigel Kennea; Nuria Gonzalez-Cinca; Shona Falconer; Andrew T M Chew; Nicholas Harper; Julia Wurie; Mary A Rutherford; Serena J Counsell; A David Edwards Journal: Ann Neurol Date: 2017-08-19 Impact factor: 10.422
Authors: Diane L Damiano; James J Pekar; Susumu Mori; Andreia Vasconcellos Faria; X Ye; Elaine Stashinko; Christopher J Stanley; Katharine E Alter; Alec H Hoon; Eric M Chin Journal: Front Rehabil Sci Date: 2022-04-05