Literature DB >> 11528524

Novel polymorphisms in the IL-10 related AK155 gene (chromosome 12q15).

A Goris1, M G Marrosu, K Vandenbroeck.   

Abstract

AK155 is a recently discovered cytokine distantly related to IL-10. Its gene is located on chromosome 12q15, a region that is likely to harbour susceptibility genes for autoimmune and allergic diseases. We provide here identification and characterization of two microsatellite polymorphisms at the AK155 locus, i.e. D12S2511 and D12S2510. The first is located in the third intron and the second in the 3' region of the gene. Both might be useful as markers in association or linkage studies of polygenic inflammatory or allergic diseases. No association with multiple sclerosis was found for each of these markers by means of the transmission disequilibrium test in an extended number of Sardinian simplex families.

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Year:  2001        PMID： 11528524     DOI： 10.1038/sj.gene.6363772

Source DB:  PubMed          Journal:  Genes Immun        ISSN： 1466-4879            Impact factor:   2.676


  7 in total

1.  Regulation of pulmonary graft-versus-host disease by IL-26+CD26+CD4 T lymphocytes.

Authors:  Kei Ohnuma; Ryo Hatano; Thomas M Aune; Haruna Otsuka; Satoshi Iwata; Nam H Dang; Taketo Yamada; Chikao Morimoto
Journal:  J Immunol       Date:  2015-03-18       Impact factor: 5.422

2.  T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26.

Authors:  Stephan Meller; Jeremy Di Domizio; Kui S Voo; Heike C Friedrich; Georgios Chamilos; Dipyaman Ganguly; Curdin Conrad; Josh Gregorio; Didier Le Roy; Thierry Roger; John E Ladbury; Bernhard Homey; Stanley Watowich; Robert L Modlin; Dimitrios P Kontoyiannis; Yong-Jun Liu; Stefan T Arold; Michel Gilliet
Journal:  Nat Immunol       Date:  2015-07-13       Impact factor: 25.606

Review 3.  Interleukin-26: an IL-10-related cytokine produced by Th17 cells.

Authors:  Raymond P Donnelly; Faruk Sheikh; Harold Dickensheets; Ram Savan; Howard A Young; Mark R Walter
Journal:  Cytokine Growth Factor Rev       Date:  2010-10-14       Impact factor: 7.638

Review 4.  IL-26, a Cytokine With Roles in Extracellular DNA-Induced Inflammation and Microbial Defense.

Authors:  Vincent Larochette; Charline Miot; Caroline Poli; Elodie Beaumont; Philippe Roingeard; Helmut Fickenscher; Pascale Jeannin; Yves Delneste
Journal:  Front Immunol       Date:  2019-02-12       Impact factor: 7.561

Review 5.  T Cell Extracellular Traps: Tipping the Balance Between Skin Health and Disease.

Authors:  Kelsey Ouyang; Nicole Oparaugo; Amanda M Nelson; George W Agak
Journal:  Front Immunol       Date:  2022-06-20       Impact factor: 8.786

Review 6.  Advances in T Helper 17 Cell Biology: Pathogenic Role and Potential Therapy in Multiple Sclerosis.

Authors:  Elisabetta Volpe; Luca Battistini; Giovanna Borsellino
Journal:  Mediators Inflamm       Date:  2015-12-07       Impact factor: 4.711

7.  The cationic cytokine IL-26 differentially modulates virus infection in culture.

Authors:  Oliver Braum; Michael Klages; Helmut Fickenscher
Journal:  PLoS One       Date:  2013-07-10       Impact factor: 3.240
  7 in total

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