| Literature DB >> 11528386 |
L F Barcellos1, S Caillier, L Dragone, M Elder, E Vittinghoff, P Bucher, R R Lincoln, M Pericak-Vance, J L Haines, A Weiss, S L Hauser, J R Oksenberg.
Abstract
A C-->G nucleotide transition in exon 4 of PTPRC (encoding protein-tyrosine phosphatase receptor-type C, also known as CD45) was recently reported to be genetically associated with the development of multiple sclerosis (MS). We performed an extensive evaluation of this polymorphism using large family-based and case-control comparisons. Overall, we observed no evidence of genetic association between the PTPRC polymorphism and MS susceptibility or disease course.Entities:
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Year: 2001 PMID： 11528386 DOI： 10.1038/ng722
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330