| Literature DB >> 11528376 |
Abstract
Certain human cancers and carcinogen-induced rodent tumors commonly contain Kras2 mutations. This activated form of ras has always been described as a dominant oncogene. A new study indicates that wildtype Kras2 has properties of a tumor suppressor gene and may have the capacity to reduce the transforming potential of oncogenically activated ras.Entities:
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Year: 2001 PMID： 11528376 DOI： 10.1038/ng0901-3
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330