M R Deschenes1, A A Britt, W C Chandler. 1. Department of Kinesiology, The College of William & Mary, Williamsburg, VA 23187-8795, USA. mrdesc@wm.edu
Abstract
PURPOSE: The objective of this investigation was to determine whether morphological adaptations to unloading are different in young adult and aged skeletal muscle. METHODS: Sixteen young adult (8-month) Fischer 344 rats were randomly assigned to either a control or hindlimb suspension (HS) group. Sixteen aged (22-month) rats were similarly assigned to either control or HS conditions. After 4 wk, animals were euthanized and soleus and EDL muscles were histochemically analyzed. RESULTS: In controls, neither the soleus nor EDL displayed age-related differences in fiber size or composition. Unloading elicited fiber atrophy of the soleus in both age groups but to a greater extent (P < 0.05) in aged rats. Only in aged solei were HS-induced fiber type conversions (Type I --> II) detected. In the EDL, unloading caused atrophy only among the aged. CONCLUSION: These data suggest that aged muscle experiences greater detriment as a result of unloading. This may have important consequences in the aged because they are more likely to be restricted to bed rest or limb immobilization due to falls and other afflictions.
PURPOSE: The objective of this investigation was to determine whether morphological adaptations to unloading are different in young adult and aged skeletal muscle. METHODS: Sixteen young adult (8-month) Fischer 344 rats were randomly assigned to either a control or hindlimb suspension (HS) group. Sixteen aged (22-month) rats were similarly assigned to either control or HS conditions. After 4 wk, animals were euthanized and soleus and EDL muscles were histochemically analyzed. RESULTS: In controls, neither the soleus nor EDL displayed age-related differences in fiber size or composition. Unloading elicited fiber atrophy of the soleus in both age groups but to a greater extent (P < 0.05) in aged rats. Only in aged solei were HS-induced fiber type conversions (Type I --> II) detected. In the EDL, unloading caused atrophy only among the aged. CONCLUSION: These data suggest that aged muscle experiences greater detriment as a result of unloading. This may have important consequences in the aged because they are more likely to be restricted to bed rest or limb immobilization due to falls and other afflictions.
Authors: Michael R Deschenes; Matthew A Adan; Maria C Kapral; Kaitlin A Kressin; Colleen M Leathrum; Anna Seo; Shuhan Li; Ellen C Schaffrey Journal: J Neurosci Res Date: 2017-07-31 Impact factor: 4.164
Authors: Leslie M Baehr; Daniel W D West; Andrea G Marshall; George R Marcotte; Keith Baar; Sue C Bodine Journal: J Appl Physiol (1985) Date: 2017-03-23
Authors: M Venturelli; P Saggin; E Muti; F Naro; L Cancellara; L Toniolo; C Tarperi; E Calabria; R S Richardson; C Reggiani; F Schena Journal: Acta Physiol (Oxf) Date: 2015-05-28 Impact factor: 6.311
Authors: Stephen E Alway; Brian T Bennett; Joseph C Wilson; Neile K Edens; Suzette L Pereira Journal: Exp Gerontol Date: 2013-12-03 Impact factor: 4.032