Literature DB >> 11527822

Expression of natural peptide antibiotics in human articular cartilage and synovial membrane.

F Paulsen1, T Pufe, W Petersen, B Tillmann.   

Abstract

In view of frequent present use of invasive procedures on limb joints, it is astonishing that articular joint inflammation is a rare event. We questioned whether antimicrobial peptides play a role in protecting human articular cartilage and synovial membrane against inflammatory agents. Our results implicate defensins in the protection of human articular joints against pathogens.

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Year:  2001        PMID： 11527822      PMCID： PMC96190          DOI： 10.1128/CDLI.8.5.1021-1023.2001

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN： 1071-412X


  8 in total

1.  Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epithelia.

Authors:  J Harder; U Meyer-Hoffert; L M Teran; L Schwichtenberg; J Bartels; S Maune; J M Schröder
Journal:  Am J Respir Cell Mol Biol       Date:  2000-06       Impact factor: 6.914

2.  Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells.

Authors:  C Zhao; I Wang; R I Lehrer
Journal:  FEBS Lett       Date:  1996-11-04       Impact factor: 4.124

3.  A peptide antibiotic from human skin.

Authors:  J Harder; J Bartels; E Christophers; J M Schröder
Journal:  Nature       Date:  1997-06-26       Impact factor: 49.962

Review 4.  Pyogenic arthritis in adults.

Authors:  J J Dubost; M Soubrier; B Sauvezie
Journal:  Joint Bone Spine       Date:  2000-01       Impact factor: 4.929

5.  Defensins are mitogenic for epithelial cells and fibroblasts.

Authors:  C J Murphy; B A Foster; M J Mannis; M E Selsted; T W Reid
Journal:  J Cell Physiol       Date:  1993-05       Impact factor: 6.384

6.  Defensin modulates tissue-type plasminogen activator and plasminogen binding to fibrin and endothelial cells.

Authors:  A A Higazi; T Ganz; K Kariko; D B Cines
Journal:  J Biol Chem       Date:  1996-07-26       Impact factor: 5.157

Review 7.  Defensins: a family of antimicrobial and cytotoxic peptides.

Authors:  B L Kagan; T Ganz; R I Lehrer
Journal:  Toxicology       Date:  1994-02-28       Impact factor: 4.221

8.  Epithelial antibiotics induced at sites of inflammation.

Authors:  B S Schonwetter; E D Stolzenberg; M A Zasloff
Journal:  Science       Date:  1995-03-17       Impact factor: 47.728
  8 in total
  6 in total

Review 1.  Multifunctional antimicrobial peptides: therapeutic targets in several human diseases.

Authors:  Mohamed Zaiou
Journal:  J Mol Med (Berl)       Date:  2007-01-10       Impact factor: 4.599

2.  Expression of β-defensin-4 in "an in vivo and ex vivo model" of human osteoarthritic knee meniscus.

Authors:  Giuseppe Musumeci; Maria Luisa Carnazza; Rosalia Leonardi; Carla Loreto
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2011-08-31       Impact factor: 4.342

3.  The role of human beta-defensin-2 in bone.

Authors:  D Varoga; M Tohidnezhad; F Paulsen; C J Wruck; L Brandenburg; R Mentlein; S Lippross; J Hassenpflug; L Besch; M Müller; C Jürgens; A Seekamp; L Schmitt; T Pufe
Journal:  J Anat       Date:  2008-12       Impact factor: 2.610

4.  Osteoblasts participate in the innate immunity of the bone by producing human beta defensin-3.

Authors:  D Varoga; C J Wruck; M Tohidnezhad; L Brandenburg; F Paulsen; R Mentlein; A Seekamp; L Besch; T Pufe
Journal:  Histochem Cell Biol       Date:  2008-10-17       Impact factor: 4.304

5.  The antimicrobial peptide HBD-2 and the Toll-like receptors-2 and -4 are induced in synovial membranes in case of septic arthritis.

Authors:  D Varoga; E Klostermeier; F Paulsen; C Wruck; S Lippross; L O Brandenburg; M Tohidnezhad; A Seekamp; B Tillmann; T Pufe
Journal:  Virchows Arch       Date:  2009-05-03       Impact factor: 4.064

Review 6.  Novel therapeutic interventions towards improved management of septic arthritis.

Authors:  Jian Wang; Liucai Wang
Journal:  BMC Musculoskelet Disord       Date:  2021-06-09       Impact factor: 2.362
  6 in total

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