| Literature DB >> 11527733 |
T Matsuda1, T Aoki, T Ohgiya, T Koshi, M Ohkuchi, H Shigyo.
Abstract
New pyridazine derivatives were prepared, and their abilities to inhibit IL-1beta production were evaluated. Some compounds showed potent inhibitory activity against IL-1beta production in HL-60 cells stimulated with lipopolysaccharide (LPS). The synthesis and structure-activity relationships of these compounds are described.Entities:
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Year: 2001 PMID： 11527733 DOI： 10.1016/s0960-894x(01)00432-2
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823