Literature DB >> 11527725

Vinyl sulfonium as novel proteolytic enzyme inhibitor.

G Zhao1, Z S Zhou.   

Abstract

Vinyl sulfoniums were synthesized from vinyl sulfides by methylation, and inhibited the proteolytic enzyme papain. Inhibition studies suggest a mechanism by which the vinyl sulfonium inhibitor covalently and irreversibly modifies the enzyme.

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Year:  2001        PMID： 11527725     DOI： 10.1016/s0960-894x(01)00440-1

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Identifying Unknown Enzyme-Substrate Pairs from the Cellular Milieu with Native Mass Spectrometry.

Authors:  Kalli C Catcott; Jing Yan; Wanlu Qu; Vicki H Wysocki; Zhaohui Sunny Zhou
Journal:  Chembiochem       Date:  2017-03-14       Impact factor: 3.164

2.  Detection and quantitation of succinimide in intact protein via hydrazine trapping and chemical derivatization.

Authors:  Joshua J Klaene; Wenqin Ni; Joshua F Alfaro; Zhaohui Sunny Zhou
Journal:  J Pharm Sci       Date:  2014-07-14       Impact factor: 3.534

3.  Radical-mediated thiodesulfonylation of the vinyl sulfones: Access to (α-fluoro)vinyl sulfides.

Authors:  Pablo R Sacasa; Jessica Zayas; Stanislaw F Wnuk
Journal:  Tetrahedron Lett       Date:  2009-09-23       Impact factor: 2.415

4.  Lepadins I-K, 3- O-(3'-Methylthio)acryloyloxy-decahydroquinoline Esters from a Bahamian Ascidian Didemnum sp. Assignment of Absolute Stereostructures.

Authors:  Sesselja Ómarsdóttir; Xiao Wang; Hong-Bing Liu; Brendan M Duggan; Tadeusz F Molinski
Journal:  J Org Chem       Date:  2018-10-26       Impact factor: 4.354

5.  Discovery of undefined protein cross-linking chemistry: a comprehensive methodology utilizing 18O-labeling and mass spectrometry.

Authors:  Min Liu; Zhongqi Zhang; Tianzhu Zang; Chris Spahr; Janet Cheetham; Da Ren; Zhaohui Sunny Zhou
Journal:  Anal Chem       Date:  2013-05-28       Impact factor: 6.986

6.  Discovery of a chemical modification by citric acid in a recombinant monoclonal antibody.

Authors:  Chris Chumsae; Liqiang Lisa Zhou; Yang Shen; Jessica Wohlgemuth; Emma Fung; Randall Burton; Czeslaw Radziejewski; Zhaohui Sunny Zhou
Journal:  Anal Chem       Date:  2014-08-27       Impact factor: 6.986

7.  Comparison of Protein N-Homocysteinylation in Rat Plasma under Elevated Homocysteine Using a Specific Chemical Labeling Method.

Authors:  Tianzhu Zang; Ligi Paul Pottenplackel; Diane E Handy; Joseph Loscalzo; Shujia Dai; Richard C Deth; Zhaohui Sunny Zhou; Jisheng Ma
Journal:  Molecules       Date:  2016-09-08       Impact factor: 4.411

8.  Site-specific conjugation of native antibody.

Authors:  Amissi Sadiki; Shefali R Vaidya; Mina Abdollahi; Gunjan Bhardwaj; Michael E Dolan; Harpreet Turna; Varnika Arora; Athul Sanjeev; Timothy D Robinson; Andrea Koid; Aashka Amin; Zhaohui Sunny Zhou
Journal:  Antib Ther       Date:  2020-12-18

9.  Discovery and characterization of a photo-oxidative histidine-histidine cross-link in IgG1 antibody utilizing ¹⁸O-labeling and mass spectrometry.

Authors:  Min Liu; Zhongqi Zhang; Janet Cheetham; Da Ren; Zhaohui Sunny Zhou
Journal:  Anal Chem       Date:  2014-05-02       Impact factor: 6.986
  9 in total

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