| Literature DB >> 11527715 |
C P Kordik1, C Luo, B C Zanoni, S L Dax, J J McNally, T W Lovenberg, S J Wilson, A B Reitz.
Abstract
1,3-Disubstituted-5-aminopyrazoles were prepared based on a lead compound found through high-throughput screening of our corporate compound library in an assay measuring affinity for the human neuropeptide Y5 receptor. The target compounds were prepared by cyclization of alpha-cyanoketones with appropriate hydrazines, followed by reduction and coupling to various sulfonamido-carboxylic acids. Several of these arylpyrazoles (e.g., 19 and 45) displayed high affinity for the human NPY Y5 receptor (<20nM IC(50)s).Entities:
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Year: 2001 PMID： 11527715 DOI： 10.1016/s0960-894x(01)00448-6
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823