Literature DB >> 11527708

Synthesis and microtubule binding of fluorescent paclitaxel derivatives.

E Baloglu1, D G Kingston, P Patel, S K Chatterjee, S L Bane.   

Abstract

The preparation of two new fluorescent derivatives of paclitaxel in which the fluorophore is bonded to paclitaxel at the C-10 position is reported. Both analogues, 10-deacetyl-10-(m-aminobenzoyl)paclitaxel (1, BTax) and 10-deacetyl-10-[7-(diethylamino) coumarin-3-carbonyl]paclitaxel (2, CTax) retain good activity as promoters of in vitro tubulin assembly. Microtubule binding enhances the emission intensity of both probes.

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Year:  2001        PMID： 11527708     DOI： 10.1016/s0960-894x(01)00453-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Synthesis of a Fluorescent Analogue of Paclitaxel That Selectively Binds Microtubules and Sensitively Detects Efflux by P-Glycoprotein.

Authors:  Molly M Lee; Zhe Gao; Blake R Peterson
Journal:  Angew Chem Int Ed Engl       Date:  2017-05-09       Impact factor: 15.336

2.  Design, synthesis and biological evaluation of a simplified fluorescently labeled discodermolide as a molecular probe to study the binding of discodermolide to tubulin.

Authors:  Jun Qi; Adam R Blanden; Susan Bane; David G I Kingston
Journal:  Bioorg Med Chem       Date:  2011-07-02       Impact factor: 3.641

3.  Phototriggerable 2',7-caged paclitaxel.

Authors:  Radu A Gropeanu; Hella Baumann; Sandra Ritz; Volker Mailänder; Thomas Surrey; Aránzazu del Campo
Journal:  PLoS One       Date:  2012-09-06       Impact factor: 3.240

4.  The distribution and retention of paclitaxel and doxorubicin in multicellular layer cultures.

Authors:  Joo-Ho Lee; Kun Na; Soo-Chang Song; Jaehwi Lee; Hyo-Jeong Kuh
Journal:  Oncol Rep       Date:  2012-01-20       Impact factor: 3.906
  4 in total

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