Literature DB >> 11527706

Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents.

M A Seefeld1, W H Miller, K A Newlander, W J Burgess, D J Payne, S F Rittenhouse, T D Moore, W E DeWolf, P M Keller, X Qiu, C A Janson, K Vaidya, A P Fosberry, M G Smyth, D D Jaworski, C Slater-Radosti, W F Huffman.   

Abstract

An SAR study of a screening lead has led to the identification of 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as inhibitors of Staphylococcus aureus enoyl acyl carrier protein reductase (FabI).

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Year:  2001        PMID： 11527706     DOI： 10.1016/s0960-894x(01)00405-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  15 in total

Review 1.  The reductase steps of the type II fatty acid synthase as antimicrobial targets.

Authors:  Yong-Mei Zhang; Ying-Jie Lu; Charles O Rock
Journal:  Lipids       Date:  2004-11       Impact factor: 1.880

2.  AG205, a novel agent directed against FabK of Streptococcus pneumoniae.

Authors:  Sho Takahata; Maiko Iida; Yumi Osaki; Jun Saito; Hideo Kitagawa; Tomohiro Ozawa; Takuji Yoshida; Shigeru Hoshiko
Journal:  Antimicrob Agents Chemother       Date:  2006-08       Impact factor: 5.191

3.  Rational questing for potential novel inhibitors of FabK from Streptococcus pneumoniae by combining FMO calculation, CoMFA 3D-QSAR modeling and virtual screening.

Authors:  Qingye Zhang; Chan Yu; Jun Min; Yan Wang; Jin He; Ziniu Yu
Journal:  J Mol Model       Date:  2010-09-23       Impact factor: 1.810

Review 4.  Facilitating Compound Entry as a Means to Discover Antibiotics for Gram-Negative Bacteria.

Authors:  Kristen A Muñoz; Paul J Hergenrother
Journal:  Acc Chem Res       Date:  2021-02-26       Impact factor: 22.384

5.  Design and synthesis of aryl ether inhibitors of the Bacillus anthracis enoyl-ACP reductase.

Authors:  Suresh K Tipparaju; Debbie C Mulhearn; Gary M Klein; Yufeng Chen; Subhasish Tapadar; Molly H Bishop; Shuo Yang; Juan Chen; Mahmood Ghassemi; Bernard D Santarsiero; James L Cook; Mary Johlfs; Andrew D Mesecar; Michael E Johnson; Alan P Kozikowski
Journal:  ChemMedChem       Date:  2008-08       Impact factor: 3.466

6.  Identification and characterization of inhibitors of bacterial enoyl-acyl carrier protein reductase.

Authors:  Losee L Ling; Jun Xian; Syed Ali; Bolin Geng; Jun Fan; Debra M Mills; Anthony C Arvanites; Hernan Orgueira; Mark A Ashwell; Gilles Carmel; Yibin Xiang; Donald T Moir
Journal:  Antimicrob Agents Chemother       Date:  2004-05       Impact factor: 5.191

Review 7.  'FAS't inhibition of malaria.

Authors:  Avadhesha Surolia; T N C Ramya; V Ramya; Namita Surolia
Journal:  Biochem J       Date:  2004-11-01       Impact factor: 3.857

8.  Discovery, characterization and comparison of inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicases.

Authors:  Daniel Aiello; Marjorie H Barnes; Esther E Biswas; Subhasis B Biswas; Shen Gu; John D Williams; Terry L Bowlin; Donald T Moir
Journal:  Bioorg Med Chem       Date:  2009-05-12       Impact factor: 3.641

9.  Design and synthesis of an indol derivative as antibacterial agent against Staphylococcus aureus.

Authors:  Hau-Heredia Lenin; Figueroa-Valverde Lauro; Rosas-Nexticapa Marcela; Herrera-Meza Socorro; López-Ramos Maria; Díaz-Cedillo Francisco; García-Cervera Elodia; Pool-Gómez Eduardo; Paat-Estrella Josefa; Cauich-Carrillo Regina; Euan-Hau Saidy
Journal:  J Chem Biol       Date:  2017-06-08

10.  Crystal structure of enoyl-acyl carrier protein reductase (FabK) from Streptococcus pneumoniae reveals the binding mode of an inhibitor.

Authors:  Jun Saito; Mototsugu Yamada; Takashi Watanabe; Maiko Iida; Hideo Kitagawa; Sho Takahata; Tomohiro Ozawa; Yasuo Takeuchi; Fukuichi Ohsawa
Journal:  Protein Sci       Date:  2008-02-27       Impact factor: 6.725
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