Literature DB >> 11527704

Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues.

D W Ludovici1, R W Kavash, M J Kukla, C Y Ho, H Ye, B L De Corte, K Andries, M P de Béthune, H Azijn, R Pauwels, H E Moereels, J Heeres, L M Koymans, M R de Jonge, K J Van Aken, F F Daeyaert, P J Lewi, K Das, E Arnold, P A Janssen.   

Abstract

A synthesis program directed toward improving the stability of imidoyl thiourea based non-nucleoside reverse transcriptase inhibitors (NNRTIs) led to the discovery of diaryltriazines (DATAs), a new class of potent NNRTIs. The synthesis and anti-HIV structure-activity relationship (SAR) studies of a series of DATA derivatives are described.

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Year:  2001        PMID： 11527704     DOI： 10.1016/s0960-894x(01)00411-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

1.  The Journey of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) from Lab to Clinic.

Authors:  Vigneshwaran Namasivayam; Murugesan Vanangamudi; Victor G Kramer; Sonali Kurup; Peng Zhan; Xinyong Liu; Jacob Kongsted; Siddappa N Byrareddy
Journal:  J Med Chem       Date:  2018-12-27       Impact factor: 7.446

2.  On the detection of multiple-binding modes of ligands to proteins, from biological, structural, and modeling data.

Authors:  Paul J Lewi; Marc de Jonge; Frits Daeyaert; Luc Koymans; Maarten Vinkers; Jan Heeres; Paul A J Janssen; Eddy Arnold; Kalyan Das; Art D Clark; Stephen H Hughes; Paul L Boyer; Marie-Pierre de Béthune; Rudi Pauwels; Koen Andries; Mike Kukla; Donald Ludovici; Bart De Corte; Robert Kavash; Chih Ho; Paul J Lewis
Journal:  J Comput Aided Mol Des       Date:  2003 Feb-Apr       Impact factor: 3.686

3.  Antiviral drug resistance and the need for development of new HIV-1 reverse transcriptase inhibitors.

Authors:  Eugene L Asahchop; Mark A Wainberg; Richard D Sloan; Cécile L Tremblay
Journal:  Antimicrob Agents Chemother       Date:  2012-06-25       Impact factor: 5.191

4.  Consensus Induced Fit Docking (cIFD): methodology, validation, and application to the discovery of novel Crm1 inhibitors.

Authors:  Ori Kalid; Dora Toledo Warshaviak; Sharon Shechter; Woody Sherman; Sharon Shacham
Journal:  J Comput Aided Mol Des       Date:  2012-09-30       Impact factor: 3.686

5.  TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1.

Authors:  Koen Andries; Hilde Azijn; Theo Thielemans; Donald Ludovici; Michael Kukla; Jan Heeres; Paul Janssen; Bart De Corte; Johan Vingerhoets; Rudi Pauwels; Marie-Pierre de Béthune
Journal:  Antimicrob Agents Chemother       Date:  2004-12       Impact factor: 5.191

6.  A series of diaryltriazines and diarylpyrimidines are highly potent nonnucleoside reverse transcriptase inhibitors with possible applications as microbicides.

Authors:  Yven Van Herrewege; Guido Vanham; Jo Michiels; Katrien Fransen; Luc Kestens; Koen Andries; Paul Janssen; Paul Lewi
Journal:  Antimicrob Agents Chemother       Date:  2004-10       Impact factor: 5.191

7.  A mechanistic and structural investigation of modified derivatives of the diaryltriazine class of NNRTIs targeting HIV-1 reverse transcriptase.

Authors:  Andrea C Mislak; Kathleen M Frey; Mariela Bollini; William L Jorgensen; Karen S Anderson
Journal:  Biochim Biophys Acta       Date:  2014-04-12

8.  Optimization of diarylazines as anti-HIV agents with dramatically enhanced solubility.

Authors:  Mariela Bollini; José A Cisneros; Krasimir A Spasov; Karen S Anderson; William L Jorgensen
Journal:  Bioorg Med Chem Lett       Date:  2013-07-08       Impact factor: 2.823

9.  Inhibition of human immunodeficiency virus type 1 infection by the candidate microbicide dapivirine, a nonnucleoside reverse transcriptase inhibitor.

Authors:  P Fletcher; S Harman; H Azijn; N Armanasco; P Manlow; D Perumal; M-P de Bethune; J Nuttall; J Romano; R Shattock
Journal:  Antimicrob Agents Chemother       Date:  2008-11-24       Impact factor: 5.191

10.  Condensation reactions of guanidines with bis-electrophiles: Formation of highly nitrogenous heterocycles.

Authors:  David M Arnold; Matthew G Laporte; Shelby M Anderson; Peter Wipf
Journal:  Tetrahedron       Date:  2013-09-09       Impact factor: 2.457
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