Stereotyped stepping associated with lesions in the bilateral medial frontoparietal cortices.

The location of higher locomotion centers in humans is not well defined. The authors describe stereotyped bipedal stepping movement in a patient with meningoencephalitis with necrotic lesions localized mainly in the bilateral medial frontoparietal cortices. The patient intermittently showed stereotyped stepping in the supine position during a stuporous state. The stereotyped stepping in this patient offers clinical evidence indicating the presence of a higher locomotion center in medial frontoparietal cortex.