| Literature DB >> 11524129 |
A J Hou1, Q S Zhao, M L Li, B Jiang, Z W Lin, H D Sun, Y P Zhou, Y Lu, Q T Zheng.
Abstract
Four 7,20-epoxy ent-kaurane diterpenoids, xerophilusins G (1) and I-K (2-4), were isolated from the leaves of Isodon xerophilus, along with four known ones, enanderianin C (5), rosthorin A (6), longikaurin B (7), and rabdoternin D (8). Their structures were determined primarily using NMR spectroscopic techniques. The structure and stereochemistry of 3 were confirmed by X-ray crystallography. Compounds 4 and 7 exhibited broad cytotoxicity against four kinds of human tumor cells (K562, HL-60, HCT, and MKN-28 cells) in the range of 2.23-15.35 and 0.30-8.61 microg/ml, respectively.Entities:
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Year: 2001 PMID： 11524129 DOI： 10.1016/s0031-9422(01)00164-9
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072