BACKGROUND: Gastroparesis is an important side-effect of end-stage renal disease because of its influence on nutritional status. METHODS: In this study, 56 equilibrated haemodialysis patients were evaluated by radioisotopic examination for gastric emptying time. These data were correlated to anthropometrical as well as biochemical parameters. RESULTS: The half-life time for gastric emptying was 83+/-34 min in the overall population, compared to 50+/-15 min in a normal reference population. Prealbumin, mean fibular nerve-conduction velocity and intra- as well as extracorpuscular folic acid were significantly different between patients with the lowest and highest gastric emptying times. Linear correlation analysis between the half-life for residual radioactivity and the remaining parameters yielded a significant correlation for blood urea nitrogen, serum folic acid, intracorpuscular folic acid, serum vitamin B(12), serum C-reactive protein, serum prealbumin and mean fibular nerve-conduction velocity. CONCLUSIONS: This study demonstrates that gastric emptying is significantly delayed in end-stage renal disease patients. The delay is associated with changes in biochemical indicators of nutritional status such as serum albumin and prealbumin.
BACKGROUND: Gastroparesis is an important side-effect of end-stage renal disease because of its influence on nutritional status. METHODS: In this study, 56 equilibrated haemodialysis patients were evaluated by radioisotopic examination for gastric emptying time. These data were correlated to anthropometrical as well as biochemical parameters. RESULTS: The half-life time for gastric emptying was 83+/-34 min in the overall population, compared to 50+/-15 min in a normal reference population. Prealbumin, mean fibular nerve-conduction velocity and intra- as well as extracorpuscular folic acid were significantly different between patients with the lowest and highest gastric emptying times. Linear correlation analysis between the half-life for residual radioactivity and the remaining parameters yielded a significant correlation for blood ureanitrogen, serum folic acid, intracorpuscular folic acid, serum vitamin B(12), serum C-reactive protein, serum prealbumin and mean fibular nerve-conduction velocity. CONCLUSIONS: This study demonstrates that gastric emptying is significantly delayed in end-stage renal diseasepatients. The delay is associated with changes in biochemical indicators of nutritional status such as serum albumin and prealbumin.
Authors: Bas Brouwers; Vincent P E G Pruniau; Elisa J G Cauwelier; Frans Schuit; Evelyne Lerut; Nadine Ectors; Jeroen Declercq; John W M Creemers Journal: J Biol Chem Date: 2013-08-11 Impact factor: 5.157