| Literature DB >> 11522660 |
K Filipsson1, M Kvist-Reimer, B Ahrén.
Abstract
The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is ubiquitously distributed in both the central and peripheral nervous systems and exerts a variety of effects. PACAP is a neuropeptide in pancreatic islets, where it has been suggested as a parasympathetic and sensory neurotransmitter. PACAP stimulates insulin secretion in a glucose-dependent manner, by an effect executed mainly through augmenting the formation of cAMP and stimulating the uptake of calcium. Accumulating evidence in animal studies points to a physiological importance of PACAP in the regulation of the insulin response to feeding. This review summarizes the current knowledge of islet actions and mechanisms and the function of PACAP.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11522660 DOI： 10.2337/diabetes.50.9.1959
Source DB: PubMed Journal: Diabetes ISSN： 0012-1797 Impact factor: 9.461