Literature DB >> 11522190

Full-length genome sequencing of HIV type 1 group O viruses isolated from a heterosexual transmission cluster in Senegal.

C T Kane1, C Montavon, M A Toure, M A Faye, A G Ndiaye, A G Diallo, I Ndoye, F Liegeois, E Delaporte, S Mboup, M Peeters.   

Abstract

In a polygamous marriage in Senegal, the husband and his two spouses were infected with HIV-1 group O. This study provides new full-length genome sequences for the two spouses (99SE-MP1299 and 99SE-MP1300) and the 3'-end LTR-tat fragment (6084 bp) for the husband (98SE-42HALD). Phylogenetic tree and diversity plot analysis revealed that the new viruses belong to HIV-1 group O and that they are closely related to each other in a cluster around ANT-70. The intrafamilial transmission occurred at most 6 years ago. The interpatient variability was highest in the envelope region, and in some regions of the envelope the strains from the two spouses do not cluster together anymore. The source of infection was in Cameroon and confirms a slow but continuous spread of HIV-1 group O viruses.

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Year:  2001        PMID： 11522190     DOI： 10.1089/088922201316912817

Source DB:  PubMed          Journal:  AIDS Res Hum Retroviruses        ISSN： 0889-2229            Impact factor:   2.205


  6 in total

1.  Autocatalytic maturation, physical/chemical properties, and crystal structure of group N HIV-1 protease: relevance to drug resistance.

Authors:  Jane M Sayer; Johnson Agniswamy; Irene T Weber; John M Louis
Journal:  Protein Sci       Date:  2010-11       Impact factor: 6.725

2.  Mechanism of dissociative inhibition of HIV protease and its autoprocessing from a precursor.

Authors:  Jane M Sayer; Annie Aniana; John M Louis
Journal:  J Mol Biol       Date:  2012-05-30       Impact factor: 5.469

3.  Regional spread of HIV-1 M subtype B in middle-aged patients by random env-C2V4 region sequencing.

Authors:  Martin Stürmer; Katrin Zimmermann; Carlos Fritzsche; Emil Reisinger; Gottfried Doelken; Annemarie Berger; Hans W Doerr; Josef Eberle; Lutz G Gürtler
Journal:  Med Microbiol Immunol       Date:  2010-03-09       Impact factor: 3.402

4.  Binding of Clinical Inhibitors to a Model Precursor of a Rationally Selected Multidrug Resistant HIV-1 Protease Is Significantly Weaker Than That to the Released Mature Enzyme.

Authors:  Joon H Park; Jane M Sayer; Annie Aniana; Xiaxia Yu; Irene T Weber; Robert W Harrison; John M Louis
Journal:  Biochemistry       Date:  2016-04-15       Impact factor: 3.162

Review 5.  Evolution and diversity of HIV-1 in Africa--a review.

Authors:  Maria A Papathanasopoulos; Gillian M Hunt; Caroline T Tiemessen
Journal:  Virus Genes       Date:  2003       Impact factor: 2.332

6.  Conservation patterns of HIV-1 RT connection and RNase H domains: identification of new mutations in NRTI-treated patients.

Authors:  André F A Santos; Renan B Lengruber; Esmeralda A Soares; Abhay Jere; Eduardo Sprinz; Ana M B Martinez; Jussara Silveira; Fernando S Sion; Vinay K Pathak; Marcelo A Soares
Journal:  PLoS One       Date:  2008-03-12       Impact factor: 3.240
  6 in total

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