| Literature DB >> 1151997 |
R W Guthrie, A Brossi, F A Mennona, J G Mullin, R W Kierstead, E Grunberg.
Abstract
Several acyloxy and alkyl derivatives of ellipticine have been prepared. In addition, a modified synthesis leading to the hitherto unobtainable 8,9-dimethoxy- and 8,9-methylenedioxyellipticines is described. Some of the derivatives described herein exhibit antitumor activity. However, none of the compounds showed activity superior to that of the naturally occurring pyridocarbazoles, ellipticine and 9-methoxyellipticine.Entities:
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Year: 1975 PMID： 1151997 DOI： 10.1021/jm00241a023
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446