| Literature DB >> 1151978 |
Abstract
In a benzomorphan bearing an antagonist side chain, introduction on the methano bridge of a hydroxyl oriented away from nitrogen has little effect on antagonist activity whereas a hydroxyl oriented toward nitrogen enhances this activity. Hydroxylation tends to decrease analgesic activity.Entities:
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Year: 1975 PMID： 1151978 DOI： 10.1021/jm00240a019
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446