| Literature DB >> 1151970 |
D T Greenwood, K B Mallion, A H Todd, R W Turner.
Abstract
Some 2-aryloxymethyl-2,3,5,6-tetrahydro-1,4-oxazines have been shown to possess marked antidepressant activity. The 1,4-oxazines were synthesized by lithium aluminum hydride reduction of the readily available 6-aryloxymethyl-2,3,5,6-tetrahydro-1,4-oxazin-3-ones. High antidepressant activity was associated with ortho substitution of the 2-phenoxymethyl group and with 1,4-oxazines devoid of 4-substituents.Entities:
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Year: 1975 PMID： 1151970 DOI： 10.1021/jm00240a009
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446