Literature DB >> 1151966

Liquid-lipquid partition coefficients by high-pressure liquid chromatography.

J M McCall.   

Abstract

Lipid-water partition values can be rapidly and reliably measured by high-pressure liquid chromatography (HPLC) on bonded octadecylsialne supports. This method has been developed and applied to a family of hypotensive triaminopyrimidine 3-oxides. The measured column retention values for this class of compounds correlate well with the values calculated by the Hansch method. We believe that this technique is an important addition to the methodology of Hansch analysis.

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Year:  1975        PMID： 1151966     DOI： 10.1021/jm00240a003

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  4 in total

1.  An increased throughput method for the determination of partition coefficients.

Authors:  L Hitzel; A P Watt; K L Locker
Journal:  Pharm Res       Date:  2000-11       Impact factor: 4.200

2.  Octanol-water partition coefficient measurements for the SAMPL6 blind prediction challenge.

Authors:  Mehtap Işık; Dorothy Levorse; David L Mobley; Timothy Rhodes; John D Chodera
Journal:  J Comput Aided Mol Des       Date:  2019-12-19       Impact factor: 3.686

3.  Influence of derivation on the lipophilicity and inhibitory actions of cardiac glycosides on myocardial Na+-K+-ATPase.

Authors:  N Dzimiri; U Fricke; W Klaus
Journal:  Br J Pharmacol       Date:  1987-05       Impact factor: 8.739

Review 4.  Partitioning and lipophilicity in quantitative structure-activity relationships.

Authors:  J C Dearden
Journal:  Environ Health Perspect       Date:  1985-09       Impact factor: 9.031
  4 in total

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