| Literature DB >> 11518629 |
K Suzuki1, S Omura, Y Ohashi, M Kawai, Y Iwata, K Tani, Y Sekine, N Takei, N Mori.
Abstract
To clarify the possible role played by calcineurin in kindling development, we examined the effects of pretreatment with FK506, a selective calcineurin inhibitor, on pentylenetetrazole (PTZ) kindling in rats. FK506 facilitated the speed of kindling induced by repeated administration of 30-mg/kg PTZ, while FK506 did not ameliorate acute seizure manifestations after a single injection of PTZ. Our results suggested that calcineurin might exert an inhibitory effect on PTZ kindling.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11518629 DOI： 10.1016/s0920-1211(01)00284-4
Source DB: PubMed Journal: Epilepsy Res ISSN： 0920-1211 Impact factor: 3.045