| Literature DB >> 1151743 |
F W Ossenberg, M Peignoux, D Bourdiau, J P Benhamou.
Abstract
The pharmacokinetics of pentobarbital, a barbiturate metabolized by the liver, was compared in normal and in hepatectomized rats. The blood concentration time curve following a single intravenous injection of pentobarbital was fitted to a two-compartment open model. Both the volume of the central compartment and the elimination rate constant were significantly reduced in hepatectomized rats. It is concluded that the liver plays a role both in the metabolism and the distribution of pentobarbital.Entities:
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Year: 1975 PMID： 1151743
Source DB: PubMed Journal: J Pharmacol Exp Ther ISSN： 0022-3565 Impact factor: 4.030