Literature DB >> 11516964

Protein kinases: getting NEKed for S6K activation.

D J Templeton1.   

Abstract

The 70/85 kDa ribosomal protein S6 kinase is regulated through the concerted actions of multiple phosphatases and kinases. A newly identified S6 kinase kinase, NEK6, appears to provide the penultimate activation step.

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Year:  2001        PMID： 11516964     DOI： 10.1016/s0960-9822(01)00361-x

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  3 in total

1.  Activation of S6K1 (p70 ribosomal protein S6 kinase 1) requires an initial calcium-dependent priming event involving formation of a high-molecular-mass signalling complex.

Authors:  Katherine M Hannan; George Thomas; Richard B Pearson
Journal:  Biochem J       Date:  2003-03-01       Impact factor: 3.857

2.  A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies.

Authors:  Paula M Fracasso; Kerry J Williams; Ronald C Chen; Joel Picus; Cynthia X Ma; Matthew J Ellis; Benjamin R Tan; Timothy J Pluard; Douglas R Adkins; Michael J Naughton; Janet S Rader; Matthew A Arquette; James W Fleshman; Allison N Creekmore; Sherry A Goodner; Lisa P Wright; Zhanfang Guo; Christine E Ryan; Yu Tao; Eliane M Soares; Shi-Rong Cai; Li Lin; Janet Dancey; Michelle A Rudek; Howard L McLeod; Helen Piwnica-Worms
Journal:  Cancer Chemother Pharmacol       Date:  2010-08-08       Impact factor: 3.333

3.  A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer.

Authors:  Cynthia X Ma; Matthew J C Ellis; Gina R Petroni; Zhanfang Guo; Shi-Rong Cai; Christine E Ryan; A Craig Lockhart; Michael J Naughton; Timothy J Pluard; Christiana M Brenin; Joel Picus; Allison N Creekmore; Tibu Mwandoro; Erin R Yarde; Jerry Reed; Mark Ebbert; Philip S Bernard; Mark Watson; Laurence A Doyle; Janet Dancey; Helen Piwnica-Worms; Paula M Fracasso
Journal:  Breast Cancer Res Treat       Date:  2012-12-15       Impact factor: 4.872
  3 in total

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