Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Protein destruction: adapting roles for Cks proteins.

Literature DB >> 11516665

Protein destruction: adapting roles for Cks proteins.

Abstract

Cks1, a subunit of cyclin-dependent kinases, has now been identified as an essential cofactor in the ubiquitination of the Cdk inhibitor p27 by the SCF(Skp2) ubiquitin ligase. This activity, which can be independent of Cdk binding, links Cks to positive growth control pathways regulating the G1/S transition and to cancer.

Entities: Disease Gene

Mesh：

Substances：

Year: 2001 PMID： 11516665 DOI： 10.1016/s0960-9822(01)00253-6

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

Keyword Cloud
Cited

29 in total

1. Protein-protein interactions involved in the recognition of p27 by E3 ubiquitin ligase.

Authors: Kui Xu; Charles Belunis; Wei Chu; David Weber; Frank Podlaski; Kuo-Sen Huang; Steven I Reed; Lyubomir T Vassilev
Journal: Biochem J Date: 2003-05-01 Impact factor: 3.857

2. Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities.

Authors: Lei Nie; Min Xu; Antoaneta Vladimirova; Xiao-Hong Sun
Journal: EMBO J Date: 2003-11-03 Impact factor: 11.598

3. Notch-induced E2A degradation requires CHIP and Hsc70 as novel facilitators of ubiquitination.

Authors: Zhong Huang; Lei Nie; Min Xu; Xiao-Hong Sun
Journal: Mol Cell Biol Date: 2004-10 Impact factor: 4.272

4. The transcriptional program of synchronous gametogenesis in Chlamydomonas reinhardtii.

Authors: J Abe; T Kubo; Y Takagi; T Saito; K Miura; H Fukuzawa; Y Matsuda
Journal: Curr Genet Date: 2004-11 Impact factor: 3.886

5. Preliminary crystallographic analysis of the Cks protein p13(suc1P90AP92A) from Schizosacharromyces pombe.

Authors: Joyanne A Kelly; Elizabeth A Williams; Matthew C J Wilce
Journal: Eur Biophys J Date: 2005-04-21 Impact factor: 1.733

6. Targeting the p27 E3 ligase SCF(Skp2) results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy.

Authors: Qing Chen; Weilin Xie; Deborah J Kuhn; Peter M Voorhees; Antonia Lopez-Girona; Derek Mendy; Laura G Corral; Veronique Plantevin Krenitsky; Weiming Xu; Laure Moutouh-de Parseval; David R Webb; Frank Mercurio; Keiichi I Nakayama; Keiko Nakayama; Robert Z Orlowski
Journal: Blood Date: 2008-02-27 Impact factor: 22.113

Protein destruction: adapting roles for Cks proteins.

1. Protein-protein interactions involved in the recognition of p27 by E3 ubiquitin ligase.

2. Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities.

3. Notch-induced E2A degradation requires CHIP and Hsc70 as novel facilitators of ubiquitination.

4. The transcriptional program of synchronous gametogenesis in Chlamydomonas reinhardtii.

5. Preliminary crystallographic analysis of the Cks protein p13(suc1P90AP92A) from Schizosacharromyces pombe.

6. Targeting the p27 E3 ligase SCF(Skp2) results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy.

7. SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.

8. Doc1 mediates the activity of the anaphase-promoting complex by contributing to substrate recognition.

9. CDK9 is constitutively expressed throughout the cell cycle, and its steady-state expression is independent of SKP2.

10. Information theoretical quantification of cooperativity in signalling complexes.