Literature DB >> 11516400

GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase.

H R Luo1, A Saiardi, E Nagata, K Ye, H Yu, T S Jung, X Luo, S Jain, A Sawa, S H Snyder.   

Abstract

Diphosphoinositol-pentakisphosphate (InsP7) and bis-diphosphoinositol tetrakisphosphate (InsP8) possess pyrophosphate bonds. InsP7 is formed from inositol hexakisphosphate (InsP6) by recently identified InsP6 kinases designated InsP6K1 and InsP6K2. We now report the identification, cloning, and characterization of a novel protein, GRAB (guanine nucleotide exchange factor for Rab3A), which interacts with both InsP6K1 and Rab3A, a Ras-like GTPase that regulates synaptic vesicle exocytosis. GRAB is a physiologic GEF (guanine nucleotide exchange factor) for Rab3A. Consistent with a role of Rab3A in synaptic vesicle exocytosis, GRAB regulates depolarization-induced release of dopamine from PC12 cells and nicotinic agonist-induced hGH release from bovine adrenal chromaffin cells. The association of InsP6K1 with GRAB fits with a role for InsP7 in vesicle exocytosis.

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Year:  2001        PMID： 11516400     DOI： 10.1016/s0896-6273(01)00384-1

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  39 in total

Review 1.  How versatile are inositol phosphate kinases?

Authors:  Stephen B Shears
Journal:  Biochem J       Date:  2004-01-15       Impact factor: 3.857

2.  A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport.

Authors:  Katarina Hattula; Johanna Furuhjelm; Airi Arffman; Johan Peränen
Journal:  Mol Biol Cell       Date:  2002-09       Impact factor: 4.138

3.  Large-scale profiling of Rab GTPase trafficking networks: the membrome.

Authors:  Cemal Gurkan; Hilmar Lapp; Christelle Alory; Andrew I Su; John B Hogenesch; William E Balch
Journal:  Mol Biol Cell       Date:  2005-06-08       Impact factor: 4.138

4.  Crystal structure of the Sec4p.Sec2p complex in the nucleotide exchanging intermediate state.

Authors:  Yusuke Sato; Shuya Fukai; Ryuichiro Ishitani; Osamu Nureki
Journal:  Proc Natl Acad Sci U S A       Date:  2007-05-08       Impact factor: 11.205

5.  HSP90 regulates cell survival via inositol hexakisphosphate kinase-2.

Authors:  Anutosh Chakraborty; Michael A Koldobskiy; Katherine M Sixt; Krishna R Juluri; Asif K Mustafa; Adele M Snowman; Damian B van Rossum; Randen L Patterson; Solomon H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-14       Impact factor: 11.205

Review 6.  Small G proteins as key regulators of pancreatic digestive enzyme secretion.

Authors:  John A Williams; Xuequn Chen; Maria E Sabbatini
Journal:  Am J Physiol Endocrinol Metab       Date:  2008-12-16       Impact factor: 4.310

7.  Intermediates in the guanine nucleotide exchange reaction of Rab8 protein catalyzed by guanine nucleotide exchange factors Rabin8 and GRAB.

Authors:  Zhong Guo; Xiaomin Hou; Roger S Goody; Aymelt Itzen
Journal:  J Biol Chem       Date:  2013-09-26       Impact factor: 5.157

8.  Inositol hexakisphosphate kinase-1 regulates behavioral responses via GSK3 signaling pathways.

Authors:  A Chakraborty; C Latapy; J Xu; S H Snyder; J-M Beaulieu
Journal:  Mol Psychiatry       Date:  2013-02-26       Impact factor: 15.992

9.  Biochemical, molecular and behavioral phenotypes of Rab3A mutations in the mouse.

Authors:  S Yang; M Farias; D Kapfhamer; J Tobias; G Grant; T Abel; M Bućan
Journal:  Genes Brain Behav       Date:  2007-02       Impact factor: 3.449

10.  Cigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate.

Authors:  Yuanfu Xu; Hongmei Li; Besnik Bajrami; Hyunjeong Kwak; Shannan Cao; Peng Liu; Jiaxi Zhou; Yuan Zhou; Haiyan Zhu; Keqiang Ye; Hongbo R Luo
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-22       Impact factor: 11.205
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