A Bener1, E Obineche, M Gillett, M A Pasha, B Bishawi. 1. Department of Community Medicine, Faculty of Medicine & Health Sciences, United Arab Emirates University, Al-Ain. abener@uaeu.ac.ae
Abstract
BACKGROUND: Previous studies have supported the association between high levels of blood lead levels (BLL) and elevated blood pressure. In addition, significant correlations between BLL and a variety of risk factors for blood pressure and diabetes mellitus have been well-established. OBJECTIVE: To examine the relationship between BLL, blood pressure and diabetes as well as other selected social and biochemical factors, among workers in the United Arab Emirates (UAE). METHODS: This comparative study included 110 industrial workers (exposed to lead in the workplace) and 110 non-industrial workers (not exposed); all were recruited in the city of Al-Ain, Abu-Dhabi Emirate, UAE and the groups were evenly matched for age, gender and nationality. RESULTS: The industrial workers had a significantly higher mean of BLL (median 81 and geometric mean (GM) 62 microg/dl) than did non-industrial workers (median 11 and GM 13 microg/dl). In the present study, the lead-exposed group also had significantly higher blood lead levels, body-mass index (BMI), systolic and diastolic blood pressures, fasting blood glucose and plasma levels of total cholesterol, lactate dehydrogenase and uric acid than did the non-exposed group. Furthermore a significant correlation between BLL and systolic blood pressure was observed. CONCLUSION: The study supports the hypothesis of a positive association between lead exposure, high blood pressure and risk of diabetes and heart disease.
BACKGROUND: Previous studies have supported the association between high levels of blood lead levels (BLL) and elevated blood pressure. In addition, significant correlations between BLL and a variety of risk factors for blood pressure and diabetes mellitus have been well-established. OBJECTIVE: To examine the relationship between BLL, blood pressure and diabetes as well as other selected social and biochemical factors, among workers in the United Arab Emirates (UAE). METHODS: This comparative study included 110 industrial workers (exposed to lead in the workplace) and 110 non-industrial workers (not exposed); all were recruited in the city of Al-Ain, Abu-Dhabi Emirate, UAE and the groups were evenly matched for age, gender and nationality. RESULTS: The industrial workers had a significantly higher mean of BLL (median 81 and geometric mean (GM) 62 microg/dl) than did non-industrial workers (median 11 and GM 13 microg/dl). In the present study, the lead-exposed group also had significantly higher blood lead levels, body-mass index (BMI), systolic and diastolic blood pressures, fasting blood glucose and plasma levels of total cholesterol, lactate dehydrogenase and uric acid than did the non-exposed group. Furthermore a significant correlation between BLL and systolic blood pressure was observed. CONCLUSION: The study supports the hypothesis of a positive association between lead exposure, high blood pressure and risk of diabetes and heart disease.
Authors: Selina Rahman; Howard Hu; Eileen McNeely; Saleh M M Rahman; Nancy Krieger; Pamela Waterman; Junenette Peters; Cynthia Harris; Cynthia H Harris; Deborah Prothrow-Stith; Brian K Gibbs; Perry C Brown; Genita Johnson; Angela Burgess; Richard D Gragg Journal: Fla Public Health Rev Date: 2008-01-01
Authors: Mario Schootman; Elena M Andresen; Fredric D Wolinsky; Theodore K Malmstrom; J Philip Miller; Yan Yan; Douglas K Miller Journal: Am J Epidemiol Date: 2007-07-11 Impact factor: 4.897
Authors: Richard J Johnson; Santos E Perez-Pozo; Yuri Y Sautin; Jacek Manitius; Laura Gabriela Sanchez-Lozada; Daniel I Feig; Mohamed Shafiu; Mark Segal; Richard J Glassock; Michiko Shimada; Carlos Roncal; Takahiko Nakagawa Journal: Endocr Rev Date: 2009-01-16 Impact factor: 19.871
Authors: Laurie K Svoboda; Kari Neier; Kai Wang; Raymond G Cavalcante; Christine A Rygiel; Zing Tsai; Tamara R Jones; Siyu Liu; Jaclyn M Goodrich; Claudia Lalancette; Justin A Colacino; Maureen A Sartor; Dana C Dolinoy Journal: Epigenetics Date: 2020-11-08 Impact factor: 4.528
Authors: Jonaina Fiorim; Rogério F Ribeiro Júnior; Edna A Silveira; Alessandra S Padilha; Marcos Vinícius A Vescovi; Honério C de Jesus; Ivanita Stefanon; Mercedes Salaices; Dalton V Vassallo Journal: PLoS One Date: 2011-02-25 Impact factor: 3.240