| Literature DB >> 11515714 |
C Wambebe1, H Khamofu, J A Momoh, M Ekpeyong, B S Audu, O S Njoku, E A Bamgboye, R N Nasipuri, O O Kunle, J I Okogun, M N Enwerem, J G Audam, K S Gamaniel, O O Obodozie, B Samuel, G Fojule, O Ogunyale.
Abstract
The study was undertaken to determine the safety and efficacy of NIPRISAN, a phytomedicine, developed for the management of patients with Sickle Cell Disorder (SCD). The study design is a placebo-controlled double blind cross-over trial. Eighty-two (82) patients with SCD were recruited and randomised into two groups. An initial 4 month pre-trial study was undertaken to determine the similarity of the groups. The main study was conducted over a twelve-month period with crossover at six months. Safety of the drug was assessed clinically and biochemically. NIPRISAN significantly (P < 0.01) reduced the frequency of SCD crisis associated with severe pains. Acute toxicity to the liver assessed by the activities of liver enzymes, indicate that NIPRISAN is safe. Renal function assessed by the serum levels of creatinine and blood urea nitrogen remained normal. Both the clinical and laboratory results of the present phase IIB (pivot) clinical study suggest that NIPRISAN is a safe and efficacious phytomedicine for the management of patients with Sickle Cell Disorder.Entities:
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Year: 2001 PMID： 11515714 DOI： 10.1078/0944-7113-00040
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340