Glucose metabolism and insulin response in the plasma and CSF in motor neurone disease.

Plasma glucose and insulin values and insulin values were measured during an OGTT test in patients with MND and matched controls. CSF insulin and glucose levels were measured in the fasting state in 11 patients and 1 hr after a glucose load in 3 patients. There was no significant difference between the values found in the plasma or CSF of the MND patientsand controls. The possible mechansim causing anterior horn cell death in MND is discussed.