| Literature DB >> 11514172 |
D J Carini1, R F Kaltenbach, J Liu, P A Benfield, J Boylan, M Boisclair, L Brizuela, C R Burton, S Cox, R Grafstrom, B A Harrison, K Harrison, E Akamike, J A Markwalder, Y Nakano, S P Seitz, D M Sharp, G L Trainor, T M Sielecki.
Abstract
A new structural type of kinase inhibitor, containing a benzocarbazole nucleus, has been identified. Members of the series are selective for inhibition of the cyclin dependent kinase family of enzymes. Although the cdks are highly homologous, representatives of the series showed intra-cdk selectivities, especially for cdk4. SAR studies elucidated the important features of the molecules for inhibition.Entities:
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Year: 2001 PMID： 11514172 DOI： 10.1016/s0960-894x(01)00416-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823