| Literature DB >> 11514171 |
V Lisowski1, C Enguehard, J Lancelot, D Caignard, S Lambel, S Leonce, A Pierre, G Atassi, P Renard, S Rault.
Abstract
Structure-activity relationship studies of a new series of tripentones (thieno[2,3-b]pyrrolizin-8-ones), led us to prepare several derivatives with antiproliferative activities. The most promising 3-(3-hydroxy-4-methoxyphenyl)thieno[2,3-b]pyrrolizin-8-one 20 (leukemia L1210, IC(50)=15 nM) was shown to be a potent inhibitor of tubulin polymerization.Entities:
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Year: 2001 PMID： 11514171 DOI： 10.1016/s0960-894x(01)00403-6
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823