Literature DB >> 11514169

Synthesis and antiproliferative activity of epoxy and bromo compounds derived from estrone.

D R Milic1, T Kop, Z Juranic, M J Gasic, B A Solaja.   

Abstract

Based on biological properties of epoxyquinols from natural sources, bromo and epoxyquinols derived from estrone were synthesized and screened against Fem-X, HeLa and K(562) cell lines. Evidence was found that the bromine atom and the epoxy moiety significantly increase the antiproliferative activity within the series.

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Year:  2001        PMID: 11514169     DOI: 10.1016/s0960-894x(01)00402-4

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  Iron salt-promoted oxidation of steroidal phenols by m-chloroperbenzoic acid: a route to possible antitumor agents.

Authors:  Tatjana J Kop; Nataša Terzić-Jovanović; Željko Žižak; Bogdan A Šolaja; Dragana R Milić
Journal:  RSC Adv       Date:  2022-07-18       Impact factor: 4.036

  1 in total

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