| Literature DB >> 11514166 |
A Ali1, S D Aster, D W Graham, G F Patel, G E Taylor, R L Tolman, R E Painter, L L Silver, K Young, K Ellsworth, W Geissler, G S Harris.
Abstract
4-Substituted 2-amino-6-(anilino)pyrimidines have been found to be selective inhibitors of DNA polymerase III, a replicative enzyme known to be essential in the DNA synthesis of Gram-positive bacteria. Among the analogues, 18 displayed an IC(50) of 10 microM against DNA polymerase III from Staphylococcus aureus.Entities:
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Year: 2001 PMID： 11514166 DOI： 10.1016/s0960-894x(01)00407-3
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823