Literature DB >> 11514154

5-HT(3)R binding of lerisetron: an interdisciplinary approach to drug-Receptor interactions.

H S Parihar1, A Suryanarayanan, C Ma, P Joshi, P Venkataraman, M K Schulte, K S Kirschbaum.   

Abstract

The design, synthesis, and use of lerisetron-based molecular probes to investigate the 5-HT(3)R binding site are described. A SAR study, which involved distance and electronic parameter modifications of lerisetron's N-benzyl group, resulted in the discovery of a partial agonist.

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11514154     DOI： 10.1016/s0960-894x(01)00417-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Subunit rotation models activation of serotonin 5-HT3AB receptors by agonists.

Authors:  Gábor Maksay; Miklós Simonyi; Zsolt Bikádi
Journal:  J Comput Aided Mol Des       Date:  2004-10       Impact factor: 3.686

2.  3-(Fur-2-yl)-10-(2-phenylethyl)-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one, a novel adenosine receptor antagonist with A(2A)-mediated neuroprotective effects.

Authors:  Alessia Scatena; Francesco Fornai; Maria Letizia Trincavelli; Sabrina Taliani; Simona Daniele; Isabella Pugliesi; Sandro Cosconati; Claudia Martini; Federico Da Settimo
Journal:  ACS Chem Neurosci       Date:  2011-06-10       Impact factor: 4.418

3.  Toward biophysical probes for the 5-HT3 receptor: structure-activity relationship study of granisetron derivatives.

Authors:  Sanjeev Kumar V Vernekar; Hasan Y Hallaq; Guy Clarkson; Andrew J Thompson; Linda Silvestri; Sarah C R Lummis; Martin Lochner
Journal:  J Med Chem       Date:  2010-03-11       Impact factor: 7.446

4.  Functional group interactions of a 5-HT3R antagonist.

Authors:  Padmavati Venkataraman; Prasad Joshi; Srinivasan P Venkatachalan; Mani Muthalagi; Harish S Parihar; Karen S Kirschbaum; Marvin K Schulte
Journal:  BMC Biochem       Date:  2002-06-13       Impact factor: 4.059
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.