| Literature DB >> 11514150 |
Z Chen1, T P Demuth, F C Wireko.
Abstract
Two well-defined oxidative chlorination-cyclization processes have been developed for the stereoselective synthesis of a variety of 4-amido-isothiazolidinone oxide derivatives. The stereochemistry of the cyclization products was confirmed by X-ray crystallography. These new compounds were designed as bacterial serine protease inhibitors. In tests, some of them showed weak antibacterial activity.Entities:
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Year: 2001 PMID： 11514150 DOI： 10.1016/s0960-894x(01)00409-7
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823