Literature DB >> 11514139

1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI).

D A Heerding1, G Chan, W E DeWolf, A P Fosberry, C A Janson, D D Jaworski, E McManus, W H Miller, T D Moore, D J Payne, X Qiu, S F Rittenhouse, C Slater-Radosti, W Smith, D T Takata, K S Vaidya, C C Yuan, W F Huffman.   

Abstract

1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and Escherichia coli enoyl acyl carrier protein reductase (FabI) have been identified. Crystal structure data shows the inhibitor 1 bound in the enzyme active site of E. coli FabI.

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Year:  2001        PMID： 11514139     DOI： 10.1016/s0960-894x(01)00404-8

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  23 in total

1.  Structural and enzymatic analyses reveal the binding mode of a novel series of Francisella tularensis enoyl reductase (FabI) inhibitors.

Authors:  Shahila Mehboob; Kirk E Hevener; Kent Truong; Teuta Boci; Bernard D Santarsiero; Michael E Johnson
Journal:  J Med Chem       Date:  2012-06-08       Impact factor: 7.446

Review 2.  Global phenotypic screening for antimalarials.

Authors:  W Armand Guiguemde; Anang A Shelat; Jose F Garcia-Bustos; Thierry T Diagana; Francisco-Javier Gamo; R Kiplin Guy
Journal:  Chem Biol       Date:  2012-01-27

Review 3.  The reductase steps of the type II fatty acid synthase as antimicrobial targets.

Authors:  Yong-Mei Zhang; Ying-Jie Lu; Charles O Rock
Journal:  Lipids       Date:  2004-11       Impact factor: 1.880

4.  Crystallization and preliminary X-ray analysis of enoyl-acyl carrier protein reductase (FabK) from Streptococcus pneumoniae.

Authors:  Jun Saito; Mototsugu Yamada; Takashi Watanabe; Hideo Kitagawa; Yasuo Takeuchi
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2006-05-31

5.  AG205, a novel agent directed against FabK of Streptococcus pneumoniae.

Authors:  Sho Takahata; Maiko Iida; Yumi Osaki; Jun Saito; Hideo Kitagawa; Tomohiro Ozawa; Takuji Yoshida; Shigeru Hoshiko
Journal:  Antimicrob Agents Chemother       Date:  2006-08       Impact factor: 5.191

Review 6.  Challenges of antibacterial discovery.

Authors:  Lynn L Silver
Journal:  Clin Microbiol Rev       Date:  2011-01       Impact factor: 26.132

7.  Rational questing for potential novel inhibitors of FabK from Streptococcus pneumoniae by combining FMO calculation, CoMFA 3D-QSAR modeling and virtual screening.

Authors:  Qingye Zhang; Chan Yu; Jun Min; Yan Wang; Jin He; Ziniu Yu
Journal:  J Mol Model       Date:  2010-09-23       Impact factor: 1.810

8.  Identification and characterization of inhibitors of bacterial enoyl-acyl carrier protein reductase.

Authors:  Losee L Ling; Jun Xian; Syed Ali; Bolin Geng; Jun Fan; Debra M Mills; Anthony C Arvanites; Hernan Orgueira; Mark A Ashwell; Gilles Carmel; Yibin Xiang; Donald T Moir
Journal:  Antimicrob Agents Chemother       Date:  2004-05       Impact factor: 5.191

Review 9.  'FAS't inhibition of malaria.

Authors:  Avadhesha Surolia; T N C Ramya; V Ramya; Namita Surolia
Journal:  Biochem J       Date:  2004-11-01       Impact factor: 3.857

10.  Substituted diphenyl ethers as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularaemia.

Authors:  Kathleen England; Christopher am Ende; Hao Lu; Todd J Sullivan; Nicole L Marlenee; Richard A Bowen; Susan E Knudson; Dennis L Knudson; Peter J Tonge; Richard A Slayden
Journal:  J Antimicrob Chemother       Date:  2009-09-04       Impact factor: 5.790
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