Literature DB >> 11514094

Superoxide is responsible for apoptosis in rat vascular smooth muscle cells induced by alpha-tocopheryl hemisuccinate.

K Kogure1, M Morita, S Nakashima, S Hama, A Tokumura, K Fukuzawa.   

Abstract

We investigated the mechanism of cell toxicity of alpha-tocopheryl hemisuccinate (TS). TS concentration- and time-dependently induced the lactate dehydrogenase release and DNA fragmentation of rat vascular smooth muscle cells (VSMC). Exogenous addition of superoxide dismutase, but not catalase, significantly inhibited the cell toxicity of TS. The NADPH-dependent oxidase activity of VSMC was stimulated by TS treatment. The cell toxicity of TS was inhibited by NADPH oxidase inhibitor 4-(2-aminoethyl)-benzenesulfonyl fluoride. Consequently, TS-induced apoptosis of VSMC was suggested to be caused by exogenous O(2)(-) generated via the oxidase system activated with TS.

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Year:  2001        PMID： 11514094     DOI： 10.1016/s0304-4165(01)00168-4

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  8 in total

1.  The effects of vitamin E succinate on the expression of c-jun gene and protein in human gastric cancer SGC-7901 cells.

Authors:  Yan Zhao; Kun Wu; Wei Xia; Yu-Juan Shan; Li-Jie Wu; Wei-Ping Yu
Journal:  World J Gastroenterol       Date:  2002-10       Impact factor: 5.742

2.  Roles of Fas signaling pathway in vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells.

Authors:  Kun Wu; Yao Li; Yan Zhao; Yu-Juan Shan; Wei Xia; Wei-Ping Yu; Lan Zhao
Journal:  World J Gastroenterol       Date:  2002-12       Impact factor: 5.742

3.  Tocopheryl Phosphate Inhibits Rheumatoid Arthritis-Related Gene Expression In Vitro and Ameliorates Arthritic Symptoms in Mice.

Authors:  Susumu Hama; Naoko Kirimura; Aki Obara; Hirokatsu Takatsu; Kentaro Kogure
Journal:  Molecules       Date:  2022-02-20       Impact factor: 4.411

4.  ATRA promotes alpha tocopherol succinate-induced apoptosis in freshly isolated leukemic cells from chronic myeloid leukemic patients.

Authors:  Surender Kumar; Krishan Lal Khanduja; Neelam Verma; Subhash C Verma; Pramod Kumar Avti; Chander Mohan Pathak
Journal:  Mol Cell Biochem       Date:  2007-09-15       Impact factor: 3.396

5.  Alpha-tocopheryl succinate induces rapid and reversible phosphatidylserine externalization in histiocytic lymphoma through the caspase-independent pathway.

Authors:  Hirofumi Fujita; Daisuke Shiva; Toshihiko Utsumi; Tetsuya Ogino; Tomohiro Ogawa; Koichi Abe; Tatsuji Yasuda; Kozo Utsumi; Junzo Sasaki
Journal:  Mol Cell Biochem       Date:  2009-07-26       Impact factor: 3.396

Review 6.  Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II.

Authors:  Jiri Neuzil; Jeffrey C Dyason; Ruth Freeman; Lan-Feng Dong; Lubomir Prochazka; Xiu-Fang Wang; Immo Scheffler; Stephen J Ralph
Journal:  J Bioenerg Biomembr       Date:  2007-02       Impact factor: 3.853

7.  Development of a novel tocopheryl ester for suppression of lipid accumulation without cytotoxicity by optimization of dicarboxylic ester moiety.

Authors:  Misaki Yamasaki; Yuika Seto; Mizune Ozono; Michiyasu Nakao; Akira Shigenaga; Akira Otaka; Shigeki Sano; Kentaro Kogure
Journal:  Biochem Biophys Rep       Date:  2022-08-16

Review 8.  Vitamin E succinate and cancer treatment: a vitamin E prototype for selective antitumour activity.

Authors:  J Neuzil
Journal:  Br J Cancer       Date:  2003-11-17       Impact factor: 7.640
  8 in total

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