Alcohol consumption and risk for increased aortic pulse wave velocity in middle-aged Japanese men.

A 9-year longitudinal study was performed to prospectively examine the association of alcohol consumption with development of increased aortic pulse wave velocity (PWV) in 1,358 Japanese men aged 35 to 59 years with a PWV less than 8.0 m/sec and without antihypertensive medication. Three hundred fifty-nine men developed increased aortic PWV of 8.0 m/sec or more during 10,598 person-years follow-up. After controlling for potential predictors of aortic PWV, the relative risk for increased aortic PWV compared with that in nondrinkers was 1.05 (95% confidence interval [CI], 0.70 to 1.58) for those who drank 0.1 to 22.9 g/day of ethanol, 1.58 (95% CI, 0.89 to 1.91) for those who drank 23.0 to 45.9 g/day of ethanol, 1.77 (95% CI, 1.24 to 2.53) for those who drank 46.0 to 68.9 g/day of ethanol, and 1.81 (95% CI, 1.23 to 2.66) for those who drank 69.0 or more g/day of ethanol (p for trend <0.001). The relative risk for increased aortic PWV in current drinkers vs nondrinkers was stronger among men with a body mass index (BMI) less than 24.2 kg/m2 and nonsmokers than among men with a BMI 24.2 kg/m2 or more and current smokers, respectively. These results suggest that alcohol consumption is closely associated with risk for increased aortic PWV in middle-aged Japanese men.