Literature DB >> 11512673

Overlapping and differential localization of Bmp-2, Bmp-4, Msx-2 and apoptosis in the endocardial cushion and adjacent tissues of the developing mouse heart.

E Abdelwahid1, D Rice, L J Pelliniemi, E Jokinen.   

Abstract

The bone morphogenetic proteins BMP-2 and BMP-4 and the homeobox gene MSX-2 are required for normal development of many embryonic tissues. To elucidate their possible roles during the remodeling of the tubular heart into a fully septated four-chambered heart, we have localized the mRNA of Bmp-2, Bmp-4, Msx-2 and apoptotic cells in the developing mouse heart from embryonic day (E)11 to E17. mRNA was localized by in situ hybridization, and apoptotic cells by TUNEL (TDT-mediated dUTP-biotin nick end-labeling) as well as by transmission electron microscopy. By analyzing adjacent serial sections, we demonstrated that the expression of Msx-2 and Bmp-2 strikingly overlapped in the atrioventricular canal myocardium, in the atrioventricular junctional myocardium, and in the maturing myocardium of the atrioventricular valves. Bmp-4 was expressed in the outflow tract myocardium and in the endocardial cushion of the outflow tract ridges from E12 to E14. Msx-2 appeared in the mesenchyme of the atrioventricular endocardial cushion from E11 to E14, while Bmp-2 and Bmp-4 were detected between E11 and E14. Apoptotic cells were also detected in the mesenchyme of the endocardial cushion between E12 and E14. Our results suggest that BMP-2 and MSX-2 are tightly linked to the formation of the atrioventricular junction and valves and that BMP-4 is involved in the development of the outflow tract myocardium and of the endocardial cushion. In addition, BMP-2, BMP-4 and MSX-2 and apoptosis seem to be associated with differentiation of the endocardial cushion.

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Year:  2001        PMID: 11512673     DOI: 10.1007/s004410100399

Source DB:  PubMed          Journal:  Cell Tissue Res        ISSN: 0302-766X            Impact factor:   5.249


  31 in total

1.  Expression patterns of cartilage collagens and Sox9 during mouse heart development.

Authors:  Otto Rahkonen; Mikko Savontaus; Eltyeb Abdelwahid; Eero Vuorio; Eero Jokinen
Journal:  Histochem Cell Biol       Date:  2003-07-18       Impact factor: 4.304

2.  Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling.

Authors:  Wei Liu; Jennifer Selever; Degang Wang; Mei-Fang Lu; Kelvin A Moses; Robert J Schwartz; James F Martin
Journal:  Proc Natl Acad Sci U S A       Date:  2004-03-19       Impact factor: 11.205

3.  An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation.

Authors:  Mathieu Nadeau; Romain O Georges; Brigitte Laforest; Abir Yamak; Chantal Lefebvre; Janie Beauregard; Pierre Paradis; Benoit G Bruneau; Gregor Andelfinger; Mona Nemer
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-25       Impact factor: 11.205

4.  Abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal targeted deletion of Alk3/Bmpr1a receptor.

Authors:  Dina Myers Stroud; Vinciane Gaussin; John B E Burch; Cindy Yu; Yuji Mishina; Michael D Schneider; Glenn I Fishman; Gregory E Morley
Journal:  Circulation       Date:  2007-11-12       Impact factor: 29.690

Review 5.  Valvulogenesis: the moving target.

Authors:  Jonathan T Butcher; Roger R Markwald
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2007-08-29       Impact factor: 6.237

6.  Bmp2 instructs cardiac progenitors to form the heart-valve-inducing field.

Authors:  José Rivera-Feliciano; Clifford J Tabin
Journal:  Dev Biol       Date:  2006-04-04       Impact factor: 3.582

7.  BMP-2 and FGF-2 synergistically facilitate adoption of a cardiac phenotype in somatic bone marrow c-kit+/Sca-1+ stem cells.

Authors:  Brent R Degeorge; Marc Rosenberg; Volker Eckstein; Erhe Gao; Nicole Herzog; Hugo A Katus; Walter J Koch; Norbert Frey; Patrick Most
Journal:  Clin Transl Sci       Date:  2008-09       Impact factor: 4.689

8.  An essential role of Bmp4 in the atrioventricular septation of the mouse heart.

Authors:  Kai Jiao; Holger Kulessa; Kevin Tompkins; Yingna Zhou; Lorene Batts; H Scott Baldwin; Brigid L M Hogan
Journal:  Genes Dev       Date:  2003-09-15       Impact factor: 11.361

9.  Shox2 mediates Tbx5 activity by regulating Bmp4 in the pacemaker region of the developing heart.

Authors:  Sandra Puskaric; Stefanie Schmitteckert; Alessandro D Mori; Anne Glaser; Katja U Schneider; Benoit G Bruneau; Rüdiger J Blaschke; Herbert Steinbeisser; Gudrun Rappold
Journal:  Hum Mol Genet       Date:  2010-09-21       Impact factor: 6.150

10.  BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development.

Authors:  David J McCulley; Ji-One Kang; James F Martin; Brian L Black
Journal:  Dev Dyn       Date:  2008-11       Impact factor: 3.780

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